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益气健脾方治疗结肠癌外科术后的临床疗效观察 被引量:16

Clinical Efficacy of Yiqi Jianpi Fang for Treating the Patients with Colon Cancer after Surgical Operation
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摘要 目的:观察用益气健脾方治疗结肠癌外科术后患者的临床疗效及安全性。方法:60例结直肠癌患者随机分为观察组和对照组。两组患者均行根治性切除,观察组术后第2天开始服用益气健脾中药煎剂治疗,对照组仅采用术后常规西药治疗。两组连续治疗1个月后评价临床疗效。观察两组术后首次排气、排便时间、白细胞(WBC)计数,比较肠道功能恢复时间以及不良反应发生情况。结果:观察组中医证候积分临床疗效有效率为86.7%,显著高于对照组66.7%,两组中医证候积分临床疗效有效率比较有显著性差异(P<0.01)。观察组卡氏评分临床疗效有效率为90.0%,显著高于对照组70.0%,两组卡氏评分临床疗效有效率比较有显著性差异(P<0.01)。观察组治疗后白细胞计数明显著低于对照组,相比较有显著性差异(P<0.05);首次排气和排便时间明显提前,与对照组比较有显著性差异(P<0.05)。观察组Ⅲ~Ⅳ不良反应发生率为20.0%,显著低于对照组73.3%,相比较有显著性差异(P<0.01)。结论:益气健脾方应用于结肠癌手术患者临床疗效明显,可以促进患者术后肠道功能恢复,减轻术后炎性反应,且能降低患者不良反应的发生率和发生程度,因而是安全而有价值的一种治疗方法。 Objective: To observe the clinical efficacy and safety of Yiqi Jianpi fang for treating the patients with colon cancer after surgical operation. Method: Sixty cases of patients with colon cancer after surgical operation were randomly divided into observation group and control group. The all patients underwent radical resection, two days after the observation group was given the treatment of Yiqi Jianpi fang, the control group was given only conventional western medicine. The clinical efficacy was evaluated in after one month of continuous treatment, the postoperative first exhaust and defecation time, the white blood cell (WBC) count were observed, th bowel function recovery time and adverse circumstances of the two groups were compared. Result: The effective rate of traditional Chinese medicine (TCM) syndrome score of observation group was 86.7% , the was control group 66.7%, the difference was significant between the two groups (P 〈 0.01 ). The effective rate of kamofsky performance status (KPS) score of observation group was 90.0% , the control group was 70.0% , the difference was significant between the two groups ( P 〈 0. 01 ). After treatment the WBC count of observation group was significantly lower than the control group, compared the difference was significant (P 〈 0.05). The first exhaust and defecation time of observation group was significantly ahead of schedule, compared with the control group the difference was significant (P 〈 0.05). The Ⅲ- Ⅳ adverse events incidence rate of observation group was 20.0% , the control group was 73.3% , the difference was significant between the two groups (P 〈 0.01 ). Conclusion: The Yiqi Jianpi fang for treating the patients with colon cancer after surgical operation has better clinical efficacy, can promote postoperative recovery of bowel function, reduce the postoperative inflammatory response, and can reduce the incidence of adverse reaction and degree of occurrence. So it is safe and valuable as a treatment method for the colon cancer after surgical operation.
作者 杨满菊
出处 《中国实验方剂学杂志》 CAS 北大核心 2012年第13期262-265,共4页 Chinese Journal of Experimental Traditional Medical Formulae
关键词 益气健脾方 结肠癌 外科手术 临床观察 Yiqi Jianpi fang colon cancer surgical operation clinical observation
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