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自发老年性骨质疏松模型SAMP6小鼠研究进展 被引量:17

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摘要 快速老化模型小鼠(SAM)是由日本学者通过选择AKR/J系小鼠近交繁殖培育的系列快速老化小鼠模型,包括14种快速老化的P品系和4种正常老化的R品系。其中P品系的SAMP6小鼠为自发老年性骨质疏松模型,具有低峰值骨密度,
作者 段卫华
机构地区 天津中医药大学
出处 《天津中医药大学学报》 CAS 2012年第2期118-121,共4页 Journal of Tianjin University of Traditional Chinese Medicine
基金 科技部重大新药创制资助项目(2009ZX09311-002)
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参考文献24

  • 1Toshio T. Senescenee-accelerated mouse (SAM):a biogerontological resource in aging research[J].Neurobiology of Aging,1999,(02):105-110.doi:10.1016/S0197-4580(99)00008-1.
  • 2Chen HY,Zhou XG. Site-specifkc bone loss in senescenceaccelerated mouse (SAMP6):A mufine model for senile osteoporosis[J].Experimental Gerontology,2009,(03):792-798.
  • 3Kasai S,Shimizu M,Matsumura T. Consistency of low bone density across bone sites in SAMP6 laboratory mice[J].Bone and Miner Metab,2004,(03):207-214.
  • 4Chen H,Shoumura S,Emura S. Ultrastructural changes in bones of the senescence-accelerated mouse (SAMP6):a murine model for senile osteoporosis[J].Histology and Histopathology,2004,(03):677-685.
  • 5Tokutomi K,Matsuura T,Atsawasuwan P. Characterization of Mandibular Bones in Senile Osteoporotic Mice[J].Connective Tissue Research,2008,(05):361-366.doi:10.1080/03008200802325292.
  • 6Ophoff J,Venken K,Callewaert F. Sex steroids during bone growth:a comparative study between mouse models for hypogonadal and senile osteoporosis[J].Osteoporosis International,2009,(10):1749-1757.
  • 7Matthew JS,Michaeld DB,Willam J. Finite Element Analysis of the Mouse Tibia:Estimating Endocortical Strain During Three-Point Bending in SAMP60steoporotic Mice[J].Hueker The Anatomical Record Part,2005,(03):380-390.
  • 8Matthew JS,Michael DB. Mechanical Stimulation of Bone Formation is Normal in the SAMP6 Mouse[J].Calcified Tissue International,2008,(06):489-497.doi:10.1007/s00223-008-9142-5.
  • 9Okamoto Y,Takahashi K,Toriyama K. Femoral Peak Bone Mass and Osteoclast Number in an Animal Model of Age-Related Spontaneous Osteopenia[J].The Anatomical Record,2005,(02):21-28.
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