摘要
对外循环气升式生物反应器的气含率进行了试验研究 ,得出了气含率与操作条件之间的关联式。在此基础上 ,进行了井冈霉素发酵试验 ,并与 10 L 机械搅拌生物反应器进行了比较 ,实验结果表明 :当外循环气升式生物反应器的空气喷嘴直径为 1.5和 3.0 mm时 ,井冈霉素的发酵效价分别为 19975和 1895 0 u/ml,而 10 L机械搅拌生物反应器的井冈霉素发酵效价为 196 30 u/ ml。因此 ,将气升式生物反应器应用于井冈霉素的发酵是一项值得研究的工作。
Gas holdup in an external loop airlift bioreactor was investigated, through which an experimental characteristic equation was obtained. The experiments of jinggangmycin fermentation were carried out using the external loop airlift bioreactor and the mechanically stirred tank bioreactor, respectively. After a total fermentation time of 45h, fermentation titres of 19975 and 18950u/ml jinggangmycin were obtained in the external loop airlift bioreactor with a sparger hole diameter of 1.5 and 3.0mm, respectively, as compared to 19630u/ml in the mechanically stirred tank bioreactor.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2000年第2期105-108,共4页
Chinese Journal of Antibiotics
基金
浙江省自然科学基金!资助项目文号 3980 2 7
