摘要CD4＋CD25＋调节性T细胞（regulatory T cell,Tregs）是一类存在于动物和人类体内的具有抑制功能的天然Tregs,以调节自身T细胞反应为主要功能,在防止自身免疫性疾病的发生、维持自身免疫耐受等方面发挥着不可替代的作用。类风湿关节炎（RA）是一种以关节局部病变为主的自身免疫性疾病,
2Panayi GS, Lanchbury JS, Kingsley GH. The importance of the Tcell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum, 1992, 35: 729-735.
3Dai SM, Matsuno H, Nakamura H, et al. Interleukin-18 enhances monocyte tumor necrosis factor-alpha and interleukin-1 beta production induced by direct contact with T lymphocytes: implications in rheumatoid arthritis. Arthritis Rheum, 2004, 50: 432-443.
4Johnson BA, Haines GK, Harlow LA, et al. Adhesion molecule expressiou in human synovial tissue. Arthritis Rheum, 1993, 36:137-146.
5Bonecchi R, Bianchi G, Bordignon PP, et al. Differential expression of chemokine receptors and chemotactic responsiveness of Th1 and Th2 cells. J Exp Med, 1998, 187: 129-134.
6Sallusto F, Lenig D, Mackay CR, et al. Flexible programs of chemokine receptor expression on human polarized T helper 1and 2 lymphocytes. J Exp Med, 1997, 185: 785-790.
7Imai T, Nagira M, Takagi S, et al. Selective recruitment of CCR4-bearing Th2 cells towards antigen-pressing cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine. Iht Immunol, 1999, 11: 81-88.
8Ruth JH, Rottman JB, Katschke KJ Jr, et al. Selective lymphocyte chemokine receptor expression in the rheumatoid joint. Arthritis Rheum, 2001, 44: 2750-2760.
9Katschke KJ Jr, Rlottman JB, Ruth JH, et al. Differential expression of chemokine receptors on peripheral blood, synovial fluid,synovial tissue monocytes/macrophages in rheumatoid arthritis.Arthritis Rheum, 2001, 44: 1022-1032.
10Michael EW, Jonathan SC, David AF, et al. Effect of low-dose methotrexate in rheumatoid arthritis. New Engl J Med, 1985, 28:818-822.
6Crowson CS,Matteson EL,Davis JM 3rd,et al.Contribution of obesity to the rise in incidence of rheumatoid arthritis[J].Arthritis Care Res (Hoboken),2013,65 (1):71-77.
7Arkema EV,Hart JE,Bertrand KA,et al.Exposure to ultraviolet-B and risk of developing rheumatoid arthritis among women in the Nurses' Health Study[J].Ann Rheum Dis,2013,72(4):506-511.
9B(o)hler C,Radner H,Smolen JS,et al.Serological changes in the course of traditional and biological disease modifying therapy of rheumatoid arthritis[J].Ann Rheum Dis,2013,72(2):241-244.
10Dougados M,Devauchelle-Pensec V,Ferlet JF,et al.The ability of synovitis to predict structural damage in rheumatoid arthritis:a comparative study between clinical examination and ultrasound[J].Ann Rheum Dis,2013,72(5):665-671.
