摘要
目的观察不同剂量氟伐他汀对老年冠心病伴高脂血症患者的影响及其机制。方法选择老年性冠心病合并高脂血症患者86例,采用随机数字表法随机分为20 mg组和40 mg组,每组43例。20 mg组给予氟伐他汀20 mg/d治疗,40 mg组给予氟伐他汀40 mg/d治疗,连续用药12周。结果 20 mg组和40 mg组总有效率分别为81.40%和88.37%,两者比较差异无统计学意义(P>0.05)。两组患者治疗后TC、LDL-C、TG和hs-CRP较同组治疗前明显降低(P<0.05)。两组患者治疗后HDL-C较治疗前明显升高(P<0.05)。治疗后40 mg组降低TC、LDL-C、hs-CRP和升高HDL-C疗效优于20 mg组(P<0.05)。结论氟伐他汀可通过调脂作用来改善冠心病患者的近期疗效,其机制还可能与其调节血清hs-CRP水平,减轻内皮炎症状态,调节血管内皮功能有关,而40 mg/d剂量总体疗效优于20 mg/d剂量组。
Objective To explore the clinincal effect of different doses of fluvastatin in treatment of elderly patients with coronary artery disease and hyperlipidemia and its mechanism. Methods 86 aged patients with coronary heart disease and hyperlipidemia were randomly divided into group 20 mg and group 40 mg. The cases in 20 mg group was given fluvastatin 20 mg/d treatment and 40 mg group received fluvastatin 40mg/d treatment, 12 weeks for a course. Results The total effective rate in 20 mg group and 40 mg group was 81.40% and 88.37%, no significant difference between the two groups （P 〉 0.05）. The levels of TC, LDL-C, TG and hs-CRP in two groups of patients after treatment were significantly lower compared with that in the same group before treatment （ P 〈 0.05 ）. The level of HDL-C in two groups after treatment was significantly higher than that before treatment （ P 〈 0. 05 ）. The reduction of TC, LDL-C, hs-CRP and increase of HDL-C in group 40 mg after treatment were more effective than group 20 mg （P 〈 0.05）. Conclusion The effect of fluvastatin 40 mg qd is superior to that of fluvastatin 20 mg qd, which could improve the short-term efficacy of patients with coronary heart disease and the mechanism may be related to regulation of serum hs-CRP levels, reduced endothelial inflammatory state, regulation of vascular endothelial function.
出处
《中国临床保健杂志》
CAS
2012年第3期231-233,共3页
Chinese Journal of Clinical Healthcare
关键词
冠状动脉疾病
高脂血症
降血脂药
老年人
Coronary artery disease
Hyperlipidemia
Insulin resistance
Aged
