摘要
自2009年3月,甲型H1N1流感疫情相继在包括中国在内的许多国家暴发,对人体健康和社会经济发展造成了严重危害。血凝素(HA)蛋白是重要的病毒表面糖蛋白,主要有3种功能:①与宿主细胞表面受体结合;②引起病毒包膜与靶细胞间的膜融合;③刺激机体产生中和性抗体。本文综合了近年来的研究成果,对甲型H1N1流感病毒HA蛋白结构、主要功能、进化、抗原性的研究进展进行了综述。
Since March 2009, pandemic A/H1N1/2009 influenza virus has been spreading throughout many countries including China. The emerged virus caused great harm to human health and social economy. Hemagglutinin（HA） is the most important viral surface glycoprotein, mainly possessing three kinds of functions： （1）binding to host cell receptor, （2）triggering the fusion between viral envelop and target cell membrane, （3）stimulating the body to generate the neutralizing antibody. Advances in the structure, primary function, evolution and antigenicity of pandemic A/H1N1/2009 influenza virus HA protein are reviewed in this paper.
出处
《病毒学报》
CAS
CSCD
北大核心
2012年第4期444-452,共9页
Chinese Journal of Virology
