摘要
目的探讨转移性乳腺癌的循环肿瘤细胞（CTC）和血清肿瘤标志物（CEA、CAl53和CAl25）的表达水平以及两者之间的相关性。方法采用CellSearch自动检测系统检测93例转移性乳腺癌患者开始新治疗前的循环肿瘤细胞（CTC），同时采用电化学发光法检测这些患者血清肿瘤标志物（CEA、CAl53和CAl25）的表达水平。结果CTC阳性率为60％（56／93），与患者激素受体的状态、Her-2的状态、既往治疗的线数以及内脏转移无关。CEA的阳性率为56％（52／93），ER或PR阳性的患者CEA的阳性率更高（x2=4.550，P=0.045），与Her-2的状态、既往治疗的线数以及内脏转移无关；CAl53的阳性率为47％（44／93），与患者激素受体的状态、Her-2的状态、既往治疗的线数以及内脏转移无关；CAl25的阳性率为4l％（38／93）；既往治疗大于等于二线的患者CAl25的阳性率更高（X2=4．501，P=0.038），与患者激素受体的状态、Her-2的状态以及是否有内脏转移无关。CTC和CEA之间呈正相关（r=0.296，P=0.004）；CTC和CAl53之间呈正相关（r=0.286，P=0.005）；CTCs和CAl25两者之间无相关性（r=0．184，P=0．077）。结论转移性乳腺癌患者的循环肿瘤细胞（CTC）检出率高，而且与血清肿瘤标志物（CEA和CAl53）有明显相关性，提示联合检测转移性乳腺癌的循环肿瘤细胞（CTC）和血清肿瘤标志物（CEA和CAl53）可能会对其治疗决策有所帮助，同时CTC有可能成为转移性乳腺癌新的治疗靶点。
Objective To investigate the expression of circulating tumor cells in metastatic breast cancer and its relatonship with CEA,CA153 and CA125. Methods The Cell Search system was used to detect the expressions of CTCs before new line therapy, meanwhile the electroehemiluminescence was used to detect the expression of CEA, C153 and CA125 in 93 patients with metastatic breast cancer. Results 60% （56/93）metastatic breast cancer patients with ≥ 1 CTC/7.5 mL at baseline. The CTC positivity was not correlated with hormone receptor status,Her- 2 status, lines of previous treatment and visceral metastasis. The CEA positivity was 56% （ 52/93 ）. It was associated with ER or PR - positive （ X2 = 4.550, P = 0.045 ） , and was not correlated with Her - 2 status ,lines of previous treatment and visceral metastasis. CA153 positivity was 47% （44/93）. It was not correlated with hormone receptor status, Her -2 status,lines of previous treatment and visceral metastasis. CA125 positivity was 41% （38/93） , and it was associated with over one- line previous treatment（ X2 = 4.501, P = 0. 038 ）, However, CA125 positivity was not correlated with hormone receptor status, Her- 2＇s status and visceral metastasis. The CTC was positively correlated with CEA（r =0. 296,P =0. 004）. It was positively correlated with CA153 （r=0.286,P=0.005） ,and not correlated with CA125（r =0. 184,P =0.077）. Conclusion The circulatingtumor cells（CTCs） positivity was high in patients with metastatic breast cancer, but also its positivity has correlation with CEA and CA153. Our study indicated that detection of circulating tumor ceils combination with CEA and CA153 in metastatic breast cancer may be helpful for therapy, meanwhile the CTC may become a potential therapy target for metastatic breast cancer.
出处
《实用肿瘤学杂志》
CAS
2012年第3期220-224,共5页
Practical Oncology Journal
关键词
乳腺肿瘤
循环肿瘤细胞
肿瘤标记物
相关性
电化学发光
Breast neoplasms
Circulating tumor cells
Tumor markers
Correlation
Electrochemiluminescence
