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肾病综合征血脂代谢紊乱与血胆红素的关系研究 被引量:5

Relationship between hyperlipidemia and serum bilirubin in nephrotic synodrome
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摘要 目的初探肾病综合征(NS)的高脂血症的发病机制与其血胆红素的关系。方法患儿禁食6h,空腹抽取静脉血检测总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、甘油三酯(TG)、总胆固醇(CHO)、载脂蛋白B(APOB)、低密度脂蛋白(LDL—C)、载脂蛋白(a)(APOA)。结果NS组血清中TBIL、DBIL、IBIL、均低于正常对照组和肾炎组;NS组血清中TG、CHO、LDL、APOB、LDL—C、APOA均高于正常对照组和肾炎组(P〈O.01);胆红素与TG、cH0采用相关性分析:TBIL与CHO、TG呈负相关(r=-0.55、P〈0.01;r=-0.41,P〈0.01);DBIL与CHO、TG呈负相关(r=-0.61,P〈0.01;r=-0.45,P〈0.01);IBIL与CH0、TG呈负相关(r=-0.52,P〈0.01;r=-0.36,P〈0.01)。结论胆红素水平与NS患者血脂的高低呈负相关,NS的血胆红素水平明显偏低。 Objective To explore the relationship between hyperlipidemia and serum bilirubin level in nephrotic synodrome. Methods The whole subjects came from three groupes:One was nephritic syndrome. Two was chronic glomerulonephritis. The last was healthy controls. They named S group, T group, H group. S group was divided into normal and abnormal lipid parts. All items included TBIL, DBIL, IBIL, TG, CHO, APOB, LDL-C, APOA were de- tectd in vein samples which be obtained at 8:00 AM from the whole subject after stopping all foods and water for 6hours,in the meanwhile some urine bilirubine were detected too. Results Serum bilirubins in S group were lower obviously than T group and H group. Serum bilirubin in normal lipid part of S group was higher than those in abnor- mal lipid part. Conclusions The level of serum bilirubin is negative related with lipid in nephritic syndrome, and some lower bilirubin.
出处 《中国误诊学杂志》 CAS 2012年第12期2815-2817,共3页 Chinese Journal of Misdiagnostics
关键词 肾病综合征/代谢 脂类/血液 胆红素/血液 Nephrotic Syndrome/metabolism Lipids/Blood Bilirubin/Blood
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