摘要
目的探讨小牛血去蛋白提取物眼用凝胶对LASIK后主观症状缓解及客观体征改善的作用。方法选取80例(160眼)矫正视力≥1.0、拟行LASIK的患者,随机分为试验组和对照组,各40例(80眼)。术后观察后常规给予1g.L-1氟米龙滴眼液和5g.L-1左氧氟沙星滴眼液滴眼每天3次,共10d;试验组加用200g.L-1小牛血去蛋白提取物眼用凝胶,对照组加用1.5g.L-1更昔洛韦眼用凝胶,均每晚1次涂眼,持续3个月。观察并比较术后用药前及用药后2周、1个月、2个月、3个月患者主观症状(视疲劳、眼痛、畏光、流泪、异物感、干涩感)、客观体征(术后裸眼视力、泪液分泌试验、泪膜破裂时间、角膜荧光素染色)的变化。结果除对照组眼干涩感及视疲劳外,两组其余各项主观症状治疗效果均较好,治疗前后差异均有统计学意义(均为P<0.05)。用药前与用药后2周、1个月、2个月及3个月试验组角膜荧光素染色评分分别为(1.18±0.87)分、(1.11±1.04)分、(1.03±1.01)分、(0.95±0.98)分及(0.78±0.73)分,对照组分别为(1.23±1.08)分、(1.17±0.76)分、(1.10±0.98)分、(1.03±0.99)分及(0.92±0.59)分;泪膜破裂时间试验组分别为(7.78±1.87)s、(8.18±2.17)s、(8.29±3.21)s、(8.31±2.78)s及(8.39±1.41)s,对照组分别为(7.84±1.39)s、(8.01±2.98)s、(8.16±2.67)s、(8.17±1.46)s、(8.21±0.38)s;泪液分泌试验试验组分别为(12.25±3.67)mm、(12.20±3.11)mm、(11.41±3.59)mm、(11.56±1.64)mm及(10.07±4.16)mm,对照组分别为(11.97±3.90)mm、(12.08±4.39)mm、(11.14±3.21)mm、(11.91±2.42)mm及(10.85±2.67)mm。用药后两组角膜荧光素染色均降低、泪膜破裂时间均有所增加,与用药前相比差异均有统计学意义(均为P=0.000),泪液分泌试验用药后与用药前差异均无统计学意义(均为P>0.05)。眼干涩感用药2周后试验组较对照组各时间段观察均有更好恢复,差异均有统计学意义(均为P<0.05)。用药后1个月及以后对术后6项症状的综合缓解程度试验组优于对照组,差异均有统计学意义(均为P<0.05)。两组术后用药均未见角膜新生血管及Haze发生,未见不适症状及不良反应发生。结论小牛血去蛋白提取物眼用凝胶可缓解LASIK术后眼表不适症状,有促进角膜上皮修复、稳定泪膜的作用,且未见不良反应发生。
Objective To observe the effects of calf blood deproteined extract eye gel on rational symptomatic relief and corneal epithelial reparation after LASIK. Methods Eighty patients （ 160 eyes） with corrected visual acuity more than 1.0,who planed to receive the LASIK, were chosen and divided into treatment group and control group,40 cases in each group. After LASIK,the routine 1 g L-1 fluorometholone and 5 g L-1 levofloxacin eye drops were given, then calf blood deproteined extract eye gel （200 g L- 1 ） was added to treatment group and 1.5 g L -1 ganciclovir eye gel to con- trol group, one time at night. The changes of rational symptoms and objective signs were observed and compared before treatment and 2 week, 1 month,2 months and 3 months after operation. Results Except for dryness of eye and asthenopia in control group, other rational symptoms in two groups were rel ieved after therapy, there was statistical difference compared with before operation （P 〈 0.05 ）. Before treatment and 2 weeks, 1 month,2 months and 3 months, the scores of fluorescein staining in treatment group were 1.18 ±0.87,1. 11± 1.04,1.03 ±1.01,0.95 ±0.98 and 0.78 ±0.73, respectively, which in control group were 1.23 ± 1.08,1. 17 ± 0.76,1. 10 ± 0.98,1.03 ± 0. 99 and 0.92 ±0. 59, respectively; Break up time in treatment group were （7. 78 ± 1. 87） s, （8.18 ±2.17）s,（8.29±3.21）s,（8.31 ±2.78）s and （8.39 ± 1.41 ） s,respectively,which in control group were （7.84±1.39）s, （8.01±2.98）s, （8.16±2.67）s, （8.17± 1.46）s and （8.21 ± 0.38） s,respectively; The results of Schirmer I test in treatment group were （12.25 ±3.67） mm, （12.20 ±3. 11） mm, （11.41 ±3.59） mm, （ 11.56 ±1.64）mm and （ 10.07 ± 4. 16 ） mm, respectively, which in control group were （ 11.97 ± 3.90 ） mm, （12. 08±4.39）mm,（11. 14±3.21）mm,（11. 91 ±2.42） mm and （10.85 ±2.67） mm,re- spectively.
出处
《眼科新进展》
CAS
北大核心
2012年第7期636-638,641,共4页
Recent Advances in Ophthalmology
基金
国家自然科学基金资助(编号:81170826)~~
