摘要
目的 探讨上海市部分地区妊娠期孕妇碘营养状况与碘剂补充的效果。方法 采集正常饮食的产前孕妇、产妇及正常育龄妇女的尿样 ,测定尿碘浓度 ,随机选择尿碘 <10 0μg/ L ,35～ 36孕周的孕妇 ,进行补碘 (口服碘酸钾每天 180μg) ,在补碘后 2、4周和产后分别测定尿碘。新生儿出生后 (3～ 6天 )采集足跟血 ,用 EL ISA方法测定促甲状腺激素 (TSH)水平。结果 产前孕妇尿碘浓度的中位数为 198.795μg/ L ,尿碘 <10 0μg/ L的发生率为 18.31%。孕期尿碘中位数低于非孕期妇女 (P <0 .0 5 ) ,尿碘 <10 0μg/ L的发生率高于非孕妇 (P <0 .0 5 ) ,以产后 3～ 6天尿碘 <10 0μg/ L发生最高 ,为 30 .48% ,补碘组在 2、4周后尿碘明显上升 (P <0 .0 5 ) ,与对照组比较2周后尿碘高于对照组 (P <0 .0 5 ) ,产后均未补碘剂 ,尿碘 2个组无差别 ,新生儿 TSH水平两组无差别。结论 上海市部分地区有 18.31%妊娠期妇女存在碘营养缺乏 ,妊娠期每天补碘 180μg是有效的。
Objective Investigate the iodine status and the effect of administering iodine in pregnancy in Shanghai.Methods The urine iodine of 344 cases of pregnancy,82 cases of early postpartum and 54 cases of nonpregnancy women with the normal diet were determined 28.cases of less than 100μg/L urine iodine concentration in 35~36 gestation weeks were given KIO 3 180μg/day and 8 cases were control.The urine iodine was determined 2 and 4 weeks later and also postpartum.All neonatal TSH was determined by ELISA method.Results The median of urine iodine concentration of the pregnant women was 198.795μg/L.The incidence of less than 100μg/L urine iodine in pregnancy was 18.31%,higher than nonpregnant women (18.31% vs 7.41%,P<0.05),and 30.48% in early postpartum women.The urine iodine concentration of the iodine deficiency women increased after administering KIO 3 in 2~4 weeks.Conclusions There were 18.31% women of iodine deficiency in pregnancy in Shanghai and supplementation of KIO 3 180μg/day is effective. [
出处
《中国地方病学杂志》
CAS
CSCD
2000年第3期211-213,共3页
Chinese Jouranl of Endemiology
