摘要
目的 :比较单次静注哌库溴铵 0 .0 5mg /kg和 0 .0 75mg/kg的气管插管条件 ,肌松效应及对循环的影响。 方法 :2 0例择期手术病人 ,随机分为两组 (n =10 )。观察诱导插管时的最大肌松效应及起效时间 ,术中肌松维持及恢复时间。结果 :两组气管插管条件优良率分别为 90 %和 10 0 %。两组的起效时间 ,无反应期 ,T12 5 %、T175 %恢复时间 ,经统计学处理均具有显著性差异 ,P <0 .0 5。恢复指数两组大致相等。两组在注药后至插管 5min各时点心率无明显变化 ,注药后 3minMAP均明显下降 ,P <0 .0 5。结论 :哌库溴铵 0 .0 5mg/kg和 0 .0 75mg/kg均可用于诱导插管和中长时间手术的肌松维持 ,对循环的影响轻微 ,首次应用以 0 .0
Objective:The neuromuscular and cardiovascular effects and endotracheal intubating conditions of pipecuronium bromide were studied under balanced anesthesia. Methods:20 ASA I-II grade patients were randomly divided into two groups(n=10), and were induced with intravenous pipecuronium 0.05mg/kg or 0.075 mg/kg . Intubating conditions were evaluated , the onset time and the degree of neuromuscular blocked and recovered time were monitored with train-of four (TOF) technique. Heart rate( HR), mean artery pressure( MAP) were non-invasively measured during anesthesia. Results: Intubating conditions were excellent in all patients, except for one with poor intubating conditions following 0.05mg/kg. Onset time, neuromuscular blockage duration, T 1 25% and T 1 75% recovery times were significantly different in the two groups, P< 0.05 . Recovery index were similar, P>0.05. The HR were stable and kept in normal range within the whole procedure. The MAP had a fall after induction 3 min, then quickly recovered to base level. Conclusion:Pipecuronium is suitable for endotracheal intubation during induction of anesthesia, as well as for maintenance of muscle relaxation both in middle and longer surgical procedures. The cardiovascular effects after pipecuronium in both groups were minimal.
出处
《重庆医科大学学报》
CAS
CSCD
2000年第2期179-180,183,共3页
Journal of Chongqing Medical University
关键词
哌库溴铵
监测
肌松效应
循环
Pipecuronium bromide
Neuromuscular monitoring
