摘要
目的:观察低分割三维适形放疗和常规分割三维适形放疗联合TACE(transcatheter arterial chemoem-bolization)对不能手术切除的原发性肝癌合并门静脉癌栓(PVTT)的治疗效果。方法:74例不能手术切除的存在门静脉癌栓的患者,先行1-2次TACE术后,随机分为2组。A组:低分割组(38例)大体肿瘤靶区(GTV)只包括癌栓,总剂量48-55Gy,4-5Gy/次,3次/周,3-4周。B组:常规分割组(36例),GTV也只包括癌栓,总剂量54-60Gy,1.8-2.0Gy/次,5次/周,6-7周。比较两组的疗效及不良反应。结果:低分割组CR 6例,PR 10例,有效率约(CR+PR)42.1%,常规分割组CR 5例,PR 13例,有效率约50%,1,2年生存率低分割组46.4%,17.8%,常规分割组41.6%,22.2%。结论:低分割组及常规分割组对TACE术后门静脉癌栓的疗效相当,低分割组较常规分割组治疗的不良反应增加。两组不良反应均能耐受。
Objective ：To observe the therapeutic effect of different partition method three -dimensional conformal radiotherapy combined with transcatheter arterial, ehemoembolization （TACE） for primary hepatocellular carcinoma （HCC） with portal vein tumor thrombus （PVqq＇） . Methods： Seventy- four HCC patients with PVq^F were divided into two groups after TACE. Gross tumor volume（GTV） of two groups only include PVTT. The radiotherapy of Group A（38 cases） 4 - 5Gy per time ,3 times per week and the total dose was 48 - 55Gy. While the radiotherapy of group B （ 36 cases） 1.8 - 2.0Gy per time ,5 times per week and the total dose was 54 - 60Gy. The therapeutic effect and side effect were observed. Results：The effective rates （ CR ＋ PR） for group A and B were 42.1% and 50% respectively. The 1, 2 year survival rates were 46.4% , 17.8% ; 41.6%, 22.2% respectively. But there was no significant difference between both of them. Conclusion ： The therapeutic effect of two groups was similar. Compared with routine divided group, the side effect of low divided group was increased. But the side effects of both group can be tolerant.
出处
《现代肿瘤医学》
CAS
2012年第7期1407-1410,共4页
Journal of Modern Oncology
关键词
原发性肝癌
门脉癌栓
肝动脉化疗栓塞
三维适形放疗
hepatocellular carcinoma
portal vein tumor thrombus
transcatheter arterial chemoembolization
three -dimensional conformal raditherapy
