摘要
目的探讨影响系统性红斑狼疮（SLE）合并肺部感染患者预后的相关危险因素。方法回顾性分析84例SLE合并肺部感染患者的临床资料。以死亡与存活为因变量进行多因素Logistic回归分析。结果84例患者中死亡23例，病死率为27．38％。多因素Logistic回归分析表明，尿量、免疫球蛋白治疗、环磷酰胺冲击治疗、血浆白蛋白和系统性红斑狼疮疾病活动度（SLEDAI）评分为影响预后的危险因素（OR值分别为0．53、0．72、4．29、0．94、1．58，P〈0．01或〈0．05）。结论SLE合并肺部感染患者的预后是多因素共同作用的结果，环磷酰胺冲击治疗和SLEDAI评分增高是影响SLE合并肺部感染患者预后的独立危险因素，提高血浆白蛋白水平、增加尿量和应用免疫球蛋白治疗有助于降低病死率。
Objective To investigate the related risk factors of prognosis in patients with systemic lupus erythematosus （SLE） complicated with lung infection. Methods The clinical data of 84 cases with SLE complicated with lung infection were analyzed retrospectively. Multivariate Logistic regressive analysis was made with death and survival as the independent variable. Results There were 23 out of 84 patients dead, and fatality rate was 27.38%. Multivariate Logistic regressive analysis showed that the urine volume, immune globulin treatment,cyclophosphamide pulse therapy,plasma albumin and SLE disease activity （SLEDAI） score were the risk factors that influenced the prognosis （OR =0.53,0.72,4.29,0.94,1.58, respectively,P 〈 0.01 or 〈 0.05 ）. Conclusions The prognosis of patients with SLE complicated with lung infection is the result of the joint action of many factors. The higher SLEDAI score and cyclophosphamide pulse therapy are the independent risk factors of the prognosis. The increase of plasma albumin level and urine production and immune globulin treatment are helpful to decrease the fatality rate.
出处
《中国医师进修杂志》
2012年第19期28-29,共2页
Chinese Journal of Postgraduates of Medicine
