摘要
目的：研究不同海拔高度高原红细胞增多症患者红细胞流变学特性与脂质过氧化的关系。方法：对不同海拔高度（刚察县３３００ｍ，甘德县４０８０ｍ）高原红细胞增多症患者检测了红细胞滤过指数（ＥＦＩ）、红细胞免疫功能、红细胞超氧化物歧化酶（ＳＯＤ）和血浆丙二醛（ＭＤＡ）水平。结果：随着海拔的升高，ＥＦＩ、红细胞免疫复合物花环率和血浆ＭＤＡ水平上升，而红细胞Ｃ３ｂ受体花环率和红细胞ＳＯＤ随之降低；相关分析表明：红细胞ＳＯＤ与ＥＦＩ和红细胞免疫复合物花环率呈负相关（Ｐ＜０．０１）；而与红细胞Ｃ３ｂ受体花环率呈正相关；ＭＤＡ则相反。结论：随着海拔升高，高原红细胞增多症患者机体脂质过氧化反应增强，导致了红细胞变形能力降低。
AIM: To study the relationShip between erythrocyte rheological properties and lipid peroxidation in patients with high altitude polycythemia (HAPC). METHODS: Erythrocyte filtration index (EFI), RBC immune function, RBC superoxide dismutase (RBC - SOD) and plasna malondialdehyde (MDA) in 86 patients with HAPC and 88 healthy subjects at different altitudes (3300 m or 4080 m) were measured.RESULTS: EFI, RBC immune complex flower rate (RBCICFR) and plasma MDA level were increased, RBC - SOD and RBC C3b receptor flower rate (RBC C3b RFR )were decreased in pattenes with HAPC. There were masked difference between HAPC patients and healthy subjects. With increasing altitude, EFI, RBCICFR and plasma MDA level in HAPC patients were in- creased markedly, but RBC - SOD and RBC C3b RFR were decreased obviously. RBC - SOD was in negative corre- laton with EEI and RBCICFR, and positive correlation with RBCC3bRFR.Relationship betWeen plasma MDA level and hove mentioned para - meters were reversed. CONCLUSION: Lipid peroxidation in patients with HAPC were increased with increasing altitudes, which may be an important cause of decreasing erythrocyte deformability.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
2000年第5期412-414,共3页
Chinese Journal of Pathophysiology
关键词
高原海拔
红细胞增多症
丙二醛
SOD
MDA
Altitude
Polycythemia: Malondialdehyde
Superoxide dismutase
Erythrocytes
Rhelology
