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甘草酸、甘草次酸衍生物的合成及生物活性研究进展 被引量：17

Advances in Studies on The Synthesis of Glycyrrhizic acid,Glycyrrhetinic Acid Derivatives and Their Biological Activities
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摘要 甘草酸、甘草次酸是甘草中最重要的活性成分,具有广泛的生物活性,尤其是其衍生物具有显著的抗炎、抗乙肝病毒、抗艾滋病毒等活性。近年来国内外专家合成了许多结构各异的甘草酸、甘草次酸衍生物,并研究了其相关的药理活性。文章综述了近年国内外对甘草酸、甘草次酸衍生物合成及活性研究所取得的新进展。 Glycyrrhizic acid, glycyrrhetinie acid are the most important active ingredients in the Licorice root, possessing wide range of pharmacological and biological activities. Especially their derivatives show the remarkable anti - inflammatory, anti - he- patic and anti - HIV viruses. In this article, we reviewed the new progress in the studies on the synthesis of derivatives of glycyr- rhezic acid, glycyrrhetinic acid and their biological activities.
作者 雍建平
机构地区 宁夏医科大学公共卫生学院
出处 《时珍国医国药》 CAS CSCD 北大核心 2012年第6期1495-1498,共4页 Lishizhen Medicine and Materia Medica Research
基金 宁夏回族自治区自然科学基金(No.NZ10108) 宁夏医科大学博士建设开放课题(No.KF2010-12) 宁夏医科大学校级项目(No.XM201010)
关键词 甘草酸 甘草次酸 衍生物 合成 生物活性 Glycyrrhezic acid Glycyrrhetinic acid Derivatives Synthesis Biologica｜ activities
分类号 R284.2 [医药卫生—中药学]
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参考文献22

  • 1Subba Rao G S R, Kondaiah P, Sanjay K S, et al. Chemical modifica- tions of natural triterpenes - glycyrrhetinic and boswelfic acids : evalua- tion of their biological activity [ J ]. Tetrahedron ,2008,64 : 11541.
  • 2Rea K, Jens B, Wolfgang B,et al. In vitro anti - Helicobacter pylori ac- tivity of Extractum liquiritiae, glycyrrhizin and its metabolites [ J ] J. Antimicrob. Chemoth. 2004,54( 1 ) :243.
  • 3Gayathri C, Indira J, Alan M, et al. Structure - dependent inhibition of bladder and pancreatic cancer cell growth by 2 - substituted glycyrrhet- inic and ursolic acid derivatives [ J ]. Bioorg. Med. Chem. Lett, 2008, 18:2633.
  • 4Stefan S, Rene C. Synthesis and antitumour activity of glycyrrhetinic acid derivatives [ J ]. Bioorg. Med. Chem,2010,18 :7458.
  • 5Mourboul A, Brigitte L, Choi D W,et al. Synthesis and in Vitro Antiox- idant Activity of Glyeyrrhetinie Acid Derivatives Tested with the Cyto- chrome P450/NADPH System [J]. Chem. Pharm. Bu11,2004,52 ( 12 ) : 1436.
  • 6Kondratenko R M, Baltina L A, Mustafina E V,et al. The Synthesis and Antiviral Activity of Glycyrrhizic Acid Conjugates with a - D - Glu- cosamine and Some Glycosylamines [J ]. Russ. J. Bioorg. Chem, 2004, 30(3) :308.
  • 7Hae - Young P , Sung - Hwan P, Hae - Kyung Y, et al.. Anti - Allergic Activity of 1813 - Glycyrrhetinic acid - 3 - 0 -β- D - glucuronide [J]. Arch. Pharm. Res,2004,27 ( 1 ) :57.
  • 8Farina C ,Pinza M, Piffeti G. Synthesis and anti - nicer activity of new derivatives of Glycyrrhetinic oleanlic and ursolic acids [ J ]. IL Farmaco, 1998,53(1) :22.
  • 9Baltina L A. Chemical modification of glycyrrhetinic acid as a route to new bioactive copounds for medicine [ J ]. Curr. Med. Chem, 2003,10: 155.
  • 10Hoever G, Bahina L, Michaelis M. Antiviral Activity of Glycyrrhizic Acid Derivatives against SARS -Coronavirus [ J ]. J. Med. Chem,2005, 48 : 1256.

二级参考文献27

  • 1熊轶,王奎武,潘远江,孙红祥.一系列新型三环二萜的合成与抗肿瘤活性研究[J].高等学校化学学报,2006,27(11):2101-2105. 被引量：7
  • 2ShiJ. H., ZhouY. X., HeM. L., JinJ., XiaoY. C., XiaoJ. H. , WeiD. Z.. Chem. Nat. Comp.-J], 2006, 42:325-327.
  • 3UmS. J., ParkM. S., ParkS. H., HanH. S. , KwonY. J., SinH. S.. Bioorg. Med. Chem.[J],2003, 11:5345-5352.
  • 4Yoshida K. , Furihata K. , Habe H. , Yamane H. , Omori T.. Biotechnol. Lett. [J] , 2001,23:1619-1624.
  • 5Morana A. , Di Lazzaro A. , Di Lemia I. , Ponzone C. , De Rosa M.. Biotechnol. Lett. [J] , 2002, 24:1907-1911.
  • 6Fusako T. , Tom E. , Yasumitsu Y.. Jpn. Pharmacol. Ther. [ J], 2000, 28:763-770.
  • 7Fore C. , Eisenhut M. , Ragazzi E. , Zanchin G. , Armanini D.. J. Ethnopharmacol. [J] , 2005, 99:317-324.
  • 8Yang J. , Zhou L. , Wang J. P. , Wang G. J. , Davey A.. Planta Med. [J], 2008, 74:1351-1356.
  • 9Shimoyama Y. , Hirabayashi K. , Matsumoto H. , Sato T. , Shibata S. , Inoue H.. J. Pharm. Pharmacol. [J] , 2003, 55:811-817.
  • 10Yu D. L., Sakurai Y., Chen C. H., Chang F. R., Huang L., Kashiwada Y., Lee K. H.. J. Med. Chem. [J], 2006, 49: 5462- 5469.

共引文献11

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引证文献17

二级引证文献96

时珍国医国药
2012年 第6期

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