摘要
目的探讨Twist和E-cadherin在舌鳞状细胞癌(TSCC)组织和正常舌体组织中的表达及其临床意义。方法采用免疫组化SP法检测62例舌鳞状细胞癌组织中Twist与E-cadherin的表达,并随机选取10例正常舌体组织作为对照。结果 Twist在舌鳞癌组织中的阳性表达显著高于正常舌体组织(P<0.05);E-cadherin在舌鳞癌组织中的阳性表达显著低于正常舌体组织(P<0.05);Twist、E-cadherin在舌鳞癌组织中异常表达与肿瘤的临床分期、生长类型及淋巴结转移有关(P<0.05);Twist与E-cadherin在舌鳞癌组织中的表达呈显著负相关(r=-0.728,P<0.01)。结论 Twist与E-cadherin在舌鳞癌组织中的异常表达提示两者可能参与了肿瘤的浸润和转移过程,检测Twist和E-cadherin对于舌鳞癌的浸润转移及预后能进行有效地监测评估。
Objective To study the expression and significance of Twist and E-cadherin in tongue squamous cell carcinoma （TSCC）. Methods Immunohistochemistry was used to detect the expression of Twist and E-cadherin in 62 cases of TSCC and 10 cases of normal tonque mucosa tissues. Results The expression of Twist in TSCC was significantly higher than that in normal tongue tissues （P 〈 0.05 ）. The expression of E-cadherin in TSCC was significantly lower than that in normal tongue tissues（P 〈 0.05 ）. The expression of Twist and E-cadherin in TSCC was correlated with tumor infiltration, TNM stage and lymph node metastasis （P 〈 0.05 ）, but not correlated with patients＇ age, gender and tumor pathological grade （P 〈 0.05 ）. A significant negative correlation was noted between the expression of Twist and E-cadherin in TSCC（ r = -0.728 ,P 〈 0.01 ）. Conclusion The abnormal expression of Twist and E-cadherin in TSCC means that they may be involved in the invasion and metastasis of TSCC. Detection of the expressions of Twist and E-cadherin should be useful for estimating the development and prognosis of TSCC.
出处
《安徽医药》
CAS
2012年第7期941-943,共3页
Anhui Medical and Pharmaceutical Journal
