摘要
目的探讨综合疗法在原发性中枢神经系统淋巴瘤（PCNSL）治疗中的临床疗效及预后。方法回顾性分析我院2002年1月至2006年12月期间收治的96例原发性中枢神经系统淋巴瘤患者的临床资料。按照治疗方法分为两组,对照组（n=42）在手术的基础上联合放疗或化疗治疗,观察组（n=54）在手术的基础上联合放疗和化疗进行综合治疗,观察两组临床疗效及预后。结果观察组完全缓解39例（72.22%）,对照组完全缓解18例（42.86%）,两组临床疗效比较差异具有统计学意义（P〈0.05）;随访1~6年,观察组在1、3、5年及以上生存率显著高于对照组（均P〈0.05）,差异具有统计学意义。结论综合疗法应用于PCNSL治疗,疗效显著,安全稳定,对延长患者的生存期及提高患者的生命质量有重要意义。
Objective To study the clinical curative effects of comprehensive treatment for patients with primary central nervous system lymphoma （PCNSL）. Methods The clinical data of 96 cases of PCNSL from January 2002 to December 2006 in our hospital were retrospectively analyzed. The patients were divided into two groups. The control group （n=42） was given radiation or chemotherapy based on surgery, while the study group （n=54） was s given radiation and chemotherapy based on surgery. The clinical efficacy and prognosis were observed and compared between the two groups. Results 39 patients （72.22%） in the study group and 18 patients （42.86%） in the control group achieved complete response, with statistically significant difference between the two groups （P〈0.05）. During the follow-up of 1~6 year, the 1, 3, 5 year survival rates in the study group were significantly higher than those in the control group （P〈0.05）. No severe adverse effects were encountered. Conclusion Comprehensive treatment has good curative effects and plays a significant role in prolonging existence period and improving survival quality.
出处
《海南医学》
CAS
2012年第14期60-61,共2页
Hainan Medical Journal
关键词
中枢神经系统淋巴瘤
放、化疗
综合治疗
Central nervous system lymphoma； Radiation and chemotherapy； Comprehensive treatment
