摘要
以聚氨酯海绵为模板,采用浸渍法合成了孔隙率可控的羟基磷灰石(hydroxyapatite,HAP)生物支架。首先自制了羟基磷灰石粉体,并借助X射线衍射对其进行了物相组成的分析;其次,利用聚氨酯海绵自身均匀的孔隙结构,采用浸渍法制备了多孔羟基磷灰石支架。支架孔隙率的高低与浸渍次数有关,可达45%～90%。支架的扫描电子显微镜(SEM)分析显示,多孔支架孔形状近似为圆形,尺寸400μm左右。随浸渍次数的增加,支架的抗压强度会相应增高,浸渍5次可达3.51 MPa,满足临床要求。最后还对支架的生物亲和性进行了研究,结果表明制备的羟基磷灰石支架在人体环境中具有一定的生物亲和性。
Using a polyurethane sponge as a template,hydroxyapatite scaffolds with adjustable porosity were synthesized by the dipping method.First,the HAP powders were prepared and their phase composition were also analyzed.Second,the porous hydroxyapatite scaffolds were made by dipping polyurethane sponge with a uniform pore structure into slurry,and the dipping times could change the porosity of scaffolds from 45% to 90%.The pores of porous scaffolds were round in shape and 400 μm in diameter.With the dipping times increasing,the compressive strength of porous scaffolds correspondingly heightened and reached 3.51 MPa after 5 times of dipping,which could meet the clinical requirements.Finally,the biological compatibility of scaffolds was also studied and a conclusion was obtained that the hydroxyapatite scaffolds had certain biological affinity in human environments.
出处
《山东大学学报（工学版）》
CAS
北大核心
2012年第3期105-109,114,共6页
Journal of Shandong University（Engineering Science）
基金
山东省高等学校科技计划资助项目(J11LD52)
关键词
多孔羟基磷灰石
聚氨酯
浸渍
孔隙率
生物亲和性
抗压强度
porous hydroxyapatite
polyurethane
dipping
porosity
biological compatibility
compressive strength
