摘要
目的:探讨治疗外阴阴道假丝酵母菌病(VVC)的药物对阴道常见乳杆菌生长的影响。方法:VVC患者随机分为3组,分别应用咪康唑(咪康唑组)、伊曲康唑(伊曲康唑组)、制霉菌素栓(制霉菌素组)进行治疗,治疗前、后分别进行乳杆菌Nugent评分,治疗后观察患者症状缓解时间、阴道pH值、乳杆菌数量及H2O2阳性乳杆菌的检出率等。结果:患者症状缓解时间、总有效率3组间差异无统计学意义(P>0.05)。3组乳杆菌Nugent评分均较治疗前有所降低,且伊曲康唑组乳杆菌Nugent评分显著高于咪康唑组和制霉菌素组,差异有统计学意义(P<0.05)。咪康唑组、伊曲康唑组、制霉菌素组中H2O2阳性的乳杆菌分别占30.0%、60.0%和25.0%,差异有统计学意义(P<0.05),伊曲康唑组H2O2阳性的乳杆菌的检出率显著高于其余2组,差异有统计学意义(P<0.05)。结论:伊曲康唑治疗VVC疗效确切,对阴道乳杆菌生长的影响较小,有助于维护阴道正常菌群,是一种治疗VVC较理想的抗真菌药物。
Objective： To study the influence of common antifungal drugs for vulvovaginal candidiasis （VVC） on the vaginal common Lactobacilli. Methods： A total of 60 VVC patients were randomly divided into 3 groups： miconazole group （n=20）, itraconazole group （n=20） and nystatin group （n=20）. Before treatment, Nugent score of the Lactobacilli was carried out. And after treatment, the time of symptom relief, vaginal pH value, numbers of Lactobacilli and detection rate of H2OE-generating Lactobacilli were observed and analyzed. Result： There was no significant difference in the time of symptom relief and total effective rate （P〉0.05）. The Nugent score of lactoba- cillus decreased after treatment, and there was a significant difference on the Nugent score of Lactobacilli among the 3 groups （P〈0.05）. The detection rates of H202-generating Lactobacilli in miconazole group, itraconazole group and nystatin group were 30.0%, 60.0% and 25.0%, respectively, there was a significant difference among them （P〈0.05）. And the detection rate of HEO2-generating Lactobacilli in itraconazole group was significantly higher than that in miconazole group and nystatin group （P〈0.05）. Conclusion： Itraconazole was effective for the treatment of VVC, and had relatively less influence on the growth of H202-generating Lactobacilli, and it can contribute to maintain vaginal normal microflora, and could be an ideal antifungal drug for WC treatment.
出处
《生殖与避孕》
CAS
CSCD
2012年第7期500-503,共4页
Reproduction and Contraception
