摘要
目的:观察慢性氟中毒下大鼠下颌切牙釉质形态改变,建立评价大鼠氟斑牙病变程度的方法。方法:将20只Wistar大鼠按性别随机分为4组,实验雌雄二组饮用浓度为100mg/L的氟化钠双蒸水,对照雌雄二组单纯饮用双蒸水,观察8周。在自然光下,观察记录大鼠下颌切牙釉质形态改变,使用改良氟斑牙指数评价氟斑牙进展程度。结果:相比对照组,饮氟组大鼠随着氟暴露时间的增加,下颌切牙釉质透明度、光泽度及其受累范围等发生不同程度的变化;相同条件下,不同性别大鼠间氟斑牙指数无显著差异(P>0.05)。结论:改良氟斑牙指数可以客观评价大鼠氟斑牙病变程度。
Objective : To observe the changes in enamel of rat incisor under chronic fluorine poisoning, and establish a new index for evaluation of dental fluorosis in rat. Methods :20 Wistar rats were randomly divided into four groups by gender. Control groups were di- vided into male and female group ,fed with double-distilled water. Fluorosis groups were fed with double-distilled water containing 100 mg/L of F- for 8 weeks. Under natural light, the changes of the mandibular incisor enamel were recorded by digital camera. The pro- gress of dental fluorosis was evaluated by an improved dental fluorosis index. Results:Compared with control group, the enamel of dental fluorosis changed in different degrees, such as clarity, glossiness, surface defects. The progress of dental fluorosis had a significantly in- creased by drinking fluoride time. Under the same condition, dental fluorosis index of the different genders had no significant difference in sex (P 〉 0.05). Conclusions: The improved dental fluorosis index can be used to evaluate the severity of dental fluorosis in rats objectively.
出处
《口腔生物医学》
2012年第2期71-73,共3页
Oral Biomedicine
基金
江苏高校优势学科建设工程资助项目
江苏省血地寄防应用性科研课题(X200916)