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奥氮平与奋乃静治疗病毒性脑炎所致精神障碍的临床观察 被引量:10

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摘要 目的:研究奥氮平及奋乃静治疗病毒性脑炎所致精神障碍的疗效和安全性。方法:78例病毒性脑炎所致精神障碍患者随机分为奥氮平组和奋乃静组。疗程4周。用PANSS量表评定疗效,用副反应量表(TESS)、实验室检查及体重评定安全性。结果:奥氮平组有效率为89.47%,奋乃静组的有效率为65.78%,奥氮平组的疗效明显优于奋乃静组。奥氮平组的主要不良反应为口干、嗜睡、体重增加、便秘等,且多为轻、中度,患者基本能耐受,或随治疗时间的延长而消失。奋乃静组出现的不良反应主要为肌张力升高、震颤、静坐不能等,且以中、重度为主。结论:奥氮平治疗病毒性脑炎所致精神障碍的疗效确切,在安全性方面较奋乃静有明显优势,是一种安全有效的治疗病毒性脑炎所致精神障碍的非典型抗精神病药。
出处 《广西医科大学学报》 CAS 2012年第3期444-445,共2页 Journal of Guangxi Medical University
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