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Incidence investigation and analysis of hepatic stress injury after trauma

Incidence investigation and analysis of hepatic stress injury after trauma
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摘要 Objective To investigate the etiology and pathogenesis of hepatic stress injury after trauma.Methods 4 677 patients with severe trauma in 153th Hospital of PLA from Jan.2004 to Jul.2005 were enrolled in this study to investigate the incidence of hepatic stress injury,and furthermore,in combination with medical information,the possible pathogenesis was analyzed.Results The main manifestation of hepatic stress injury was the elevated ALT or AST levels(387 cases,8.3%).The incidence of hepatic stress injury after hand injury,burn injury,head injury,bone injury,abdominal injury,and thoracic injury were 16.6%,6.9%,5.6%,5.0%,3.8% and 2.0%,respectively,and among which,the incidence of hepatic stress injury after hand injury was statistically highest(P<0.01).Conclusion The total incidence of hepatic stress injury after trauma was 8.3%.Intestinal endotoxemia might be one of the beginning components of hepatic stress injury after trauma. Objective To investigate the etiology and pathogenesis of hepatic stress injury after trauma.Methods 4 677 patients with severe trauma in 153th Hospital of PLA from Jan.2004 to Jul.2005 were enrolled in this study to investigate the incidence of hepatic stress injury,and furthermore,in combination with medical information,the possible pathogenesis was analyzed.Results The main manifestation of hepatic stress injury was the elevated ALT or AST levels（387 cases,8.3%）.The incidence of hepatic stress injury after hand injury,burn injury,head injury,bone injury,abdominal injury,and thoracic injury were 16.6%,6.9%,5.6%,5.0%,3.8% and 2.0%,respectively,and among which,the incidence of hepatic stress injury after hand injury was statistically highest（P〈0.01）.Conclusion The total incidence of hepatic stress injury after trauma was 8.3%.Intestinal endotoxemia might be one of the beginning components of hepatic stress injury after trauma.
作者 WANG Quanchu ZHANG Yafei CHENG Zhengxiang
机构地区 Department of Infectious Diseases
出处 《胃肠病学和肝病学杂志》 CAS 2012年第7期661-663,共3页 Chinese Journal of Gastroenterology and Hepatology
基金 Supported by the foundating for Scientific research Itim of Jinan Military Command of PLA
关键词 Severe trauma Hepatic stress injury PATHOGENESIS Severe trauma Hepatic stress injury Pathogenesis
分类号 R575 [医药卫生—消化系统]
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  • 1Natori S, Rust C, Stadheim LM, Srinivasan A, Burgart LJ, Gores GJ. Hepatocyte apoptosis is a pathologic feature of human alcoholic hepatitis.J Hepatol 2001; 34:248-253.
  • 2Ihrke G, Neufeld EB, Meads T, Shanks MR, Cassio D, Laurent M, Schroer TA, Pagano RE, Hubbard AL. WIF-B cells: an in vitro model for studies of hepatocyte polarity. J Cell Biol 1993; 123:1761-1775.
  • 3Bender V, Bravo P, Decaens C, Cassio D. The structural and functional polarity of the hepatic human/rat hybrid WIF-B is a stable and dominant trait. Hepatology 1999; 30:1002-1010.
  • 4Schaffert CS, Todero SL, McVicker BL, Tuma PL, Sorrell MF, Tuma DJ. WIF-B cells as a model for alcohol-induced hepatocyte injury. Biochem Pharmacol 2004; 67:2167-2174.
  • 5McVicker BL, Tuma DJ, Kubik JL, Tuma PL, Casey CA. Ethanol-induced apoptosis in polarized hepatic cells possibly through regulation of the Fas pathway. Alcohol Clin Exp Res 2006; 30:1906-1915.
  • 6Diehl AM. Cytokine regulation of liver injury and repair. Immunol Rev 2000; 174:160-171.
  • 7Wu D, Cederbaurn AI. Oxidative stress mediated toxicity exerted by ethanobinducible CYP2E1. ToxicoI Appl Pharmacol 2005; 207:70-76.
  • 8Garcia-Ruiz C, Fernandez-Checa JC. Mitochondrial glutathione: hepatocellular survival-death switch. J Gastroenterol Hepatol 2006; 21 Suppl 3:S3-S6.
  • 9Oh SI, Kim CI, Chun HJ, Park SC. Chronic ethanol consumption affects glutathione status in rat liver. J Nutr 1998; 128:758-763.
  • 10Rouach H, Fataccioli V, Gentil M, French SW, Morimoto M, Nordmann R. Effect of chronic ethanol feeding on lipid peroxidation and protein oxidation in relation to liver pathology. Hepatology 1997; 25:351-355.

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胃肠病学和肝病学杂志
2012年 第7期

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