摘要
目的探讨青年人胃癌的临床病理特点及预后。方法回顾性分析2005年1月至2010年12月初治的56例青年人胃癌(年龄≤40岁)的临床资料,并随机选取同期56例老年人胃癌(年龄≥60岁)作对照。采用SPSS13.0统计软件分析青年人胃癌的临床病理特点及与预后的关系。结果 56例青年人胃癌女性比例高于男性(χ2=11.593,P=0.001),肿瘤多位于胃窦部,病理类型以低分化腺癌和未分化癌为主,高于对照组(χ2=16.586,P<0.001),临床分期以中晚期多见;术后生存中位时间为39.56个月,1、3、5年生存率分别为80.0%、52.0%、24.0%,行根治性手术患者生存率高于姑息性手术患者(χ2=5.836,P=0.016);手术方式、肿瘤大小、病理类型、临床分期是影响青年人胃癌预后的主要因素。结论青年人胃癌以女性居多,起病隐匿,确诊多为中晚期,恶性程度高,应重视青年人胃癌的早期诊断,尽早行根治性手术,有助于改善患者预后。
Objective To investigate the pathological features and prognosis of young patients with gastric carcinoma. Methods A retrospective analysis were conducted on 56 young patients with gastric carcinoma （age≤40 years） in our hospital from Jan.2005 to Dec.2010. Another 56 cases were chosen randomly from the old ones （age≥60 years） over the same period as the controls. Statistical analysis was performed by SPSS13.0 software package. Results In these 56 gastric cancer patients of the young group, the proportion of women was higher than that of men （X^2=l 1.593,P=0.001 ） and the tumors looked more often arised in gastric antrum. The gastric cancer in the young group was mainly poor differentiated adenocarcinoma and anaplastic carcinoma and the proportion was higher than the controls （X^2=16.586, P〈0.001 ）. The clinical stages of most young patients were in Ⅲ or IV stage. The median survival time after resection was 39.56 months in the young group, and the total of 1-, 3-, 5-year survival rates were 80.0%, 52.0%, 24.0% respectively. The survival rate of whom underwent radical resection was higher than that in patients underwent palliative surgery alone （X^2==5.836, P= 0.016）. In this study, surgical procedure, tumor size, pathological type and clinical stage were main factors affecting the prognosis of young patients （P〈0.05）. Conclusion Gastric cancer in the young patients is common in female and is highly malignant. Early diagnosis and early radical resection is helpful to improve the prognosis of gastric cancer.
出处
《岭南现代临床外科》
2012年第4期332-335,共4页
Lingnan Modern Clinics in Surgery
基金
广州市科技计划项目(2005Z3-E0521)
关键词
青年人
胃癌
临床病理
生存分析
Youth
Gastric cancer
Pathology
Survival rate
