摘要
目的:观察基质金属蛋白酶MMP-9在胃癌中的表达情况,探讨其在胃癌发生、发展中的临床意义。方法:采用免疫组化法,检测MMP-9在56例胃癌组织与24例正常胃粘膜中的表达情况。结果:56例原发性胃癌组织中,MMP-9阳性表达率为73.21%(41/56),高于24例正常胃粘膜的20.83%(5/24),两组比较差异有统计学意义(P<0.01);胃癌组织中MMP-9表达与TNM临床分期、淋巴结转移、浆膜浸润有关(P<0.01),与胃癌分化程度无相关性(P>0.05)。结论:基质金属蛋白酶MMP-9可能参与了胃癌发生发展过程,与胃癌的侵袭、转移密切相关,可作为判断胃癌预后的有重要参考价值的肿瘤标记物。
Objective： To observe the expression of MMP-9 in gastric cancer and to explore its clinical value in the occurrence, development of gastric cancer. Methods： The expressions of MMP-9 in gastric carcinoma tissues of 56 patients and normal gastric mucosa of 24 cases were detected by immunohistochemistry. Results： In 56 cases of primary gastric cancer, the positive rate of MMP-9 expression was 73.21% （41/56） , far higher than that of the normal gastric mucosa（20. 83% , 5/24）. The difference was significant （ P 〈 0. 01 ） ; There was a positive correlation between the expression of MMP-9 and the TNM staging, lymph node metastasis and serosal invasion and no correlation was observed between the expression of MMP-9 and differentiation of gastric cancer（ P 〉 0.05 ）. Conclusion： Matrix metalloproteinase MMP-9 may be involved in the occurrence, development process, invasion and metastasis of gastric cancer. It can be used as an important tumor marker to judge the prognosis of gastric cancer.
出处
《肿瘤预防与治疗》
2012年第4期240-242,共3页
Journal of Cancer Control And Treatment
关键词
胃癌
基质金属蛋白酶
侵袭
转移
标记物
Gastric Cancer
Matrix Metalloproteinase
Invasion
Metastasis
Marker
