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糖尿病心肌钾离子通道改变研究进展 被引量：10

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摘要 心肌细胞短暂外向钾电流(Ito)、延迟整流性外向钾电流(IK)、超快速激活型钾电流(IKur)、ATP敏感性钾通道(KATP)等钾离子通道在糖尿病(DM)模型中均发生异常改变,可引起动作电位(AP)、动作电位时程(APD)、QT间期、有效不应期(ERP)改变,以及折返、触发等活动,导致心律失常发生。DM心肌电生理改变可能与体内糖代谢紊乱造成心肌细胞葡萄糖利用障碍、ATP供给下降有关,这些改变可导致细胞骨架稳定性的破坏、基因转录的抑制和蛋白翻译水平的下降。但机制远不止这些,还需要大量的研究工作来探索心肌电生理发生的改变及其机制。
作者 李学永 刘刚 郭继鸿
机构地区 解放军第 河北医科大学第一医院心内科 北京大学人民医院心电生理室
出处 《中国心脏起搏与心电生理杂志》 2012年第3期261-264,共4页 Chinese Journal of Cardiac Pacing and Electrophysiology
基金 国家自然基金项目(项目编号:81100127) 河北省医学科学研究重点课题项目(项目编号:20100047)
关键词 心血管病学 糖尿病 综述 钾离子通道 心律失常 代谢紊乱 胰岛素抵抗
分类号 R587.1 [医药卫生—内分泌] R541.7 [医药卫生—心血管疾病]
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参考文献35

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二级参考文献56

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共引文献42

同被引文献99

  • 1沈佩玲.以高钙血症为首发表现的老年恶性淋巴瘤1例报告[J].实用老年医学,2013,27(2):174-175. 被引量：1
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引证文献10

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中国心脏起搏与心电生理杂志
2012年 第3期

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