摘要
目的探讨感染性休克早期血清甲状腺功能的变化和意义。方法选择15例感染性休克患者（休克组）和20例严重全身感染患者（感染组）在确诊后第1、3、5天应用电化学发光法测定血清三碘甲状腺原氨酸（T3）、甲状腺素（T4）、游离T3（FT3）、游离T4（FT4）、促甲状腺激素（TSH）；同期选择20例健康体检者（对照组）进行对照分析。结果感染组和休克组T1、T4明显降低（P〈0．05或P〈0．01），以APACHEII评分为标准，T1、T4的变化与严重感染患者病情危重程度密切相关（P〈0．05或P〈0．01）。结论感染性休克早期就伴有不同程度的甲状腺功能减退，并与感染危重程度密切相关。
Objective To explore the changes of thyroid （T3 ） at the early stage of septic shock. Methods There were three groups in our study：①15 patients with septic shock;②20 patients with whole body infection; ③20 healthy volunteers as the control. The concentration of serum three iodine thyroid gland original ammonia acid （ T3 ）, thyroxine （ T4 ） , free triiodothyronine （ FT3 ）, free thyroxine（ FT4） and thyroid stimulating hormone （TSH） were detected in all the subjects by ICMA at 1, 3, 5 d after diagnosis. Results The level of T3 and T4 decreased significantly in the infection group and shock group compared with the control group（P 〈 0.05 or P 〈 0.01 ）. According to APACHE II as the criteria, there was positive relationship between the concentration of serum T3 , T4 and the severity of illness in patients with infection （ P 〈 0.05 or P 〈 0.01 ）. Conclusion At the early stage of septic shock, the infection group and shock group have varying degrees of hypothyroidism, which is closely related to the severity of infection.
出处
《中国急救医学》
CAS
CSCD
北大核心
2012年第7期648-650,共3页
Chinese Journal of Critical Care Medicine
基金
贵阳市卫生局2011年医药卫生项目（筑卫发[2010]578号）
关键词
感染性休克
早期
甲状腺功能
Septic shock
Early stage
Thyroid function
