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普瑞巴林的临床应用与不良反应 被引量：18

Clinical application and adverse effects of pregabalin
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摘要 普瑞巴林(pregabalin)是一种新型的神经递质γ-氨基丁酸(GABA)结构类似物,主要用于治疗成人癫痫症、带状疱疹后神经痛、糖尿病神经病变有关的神经性疼痛和纤维肌痛等。文中总结了普瑞巴林的临床应用和不良反应,建议普瑞巴林的维持剂量为300 mg.d-1,超过600 mg.d-1不会增强疗效,反而会增加普瑞巴林不良反应的发生率。 Pregabalin is a new structural analogue of the neurotransmitter regulator, y-aminobutyric acid. It is mainly used for management of partial seizures in adults, postherpetic neuralgia （PHN） , diabetic neuropathy and ibromyalgia. The recommended maintenance dosage is 300 mg.d-l. Dosages higher than 600 mg.d-1 provide no additional benefit, in stead, it may increase risk of adverse reaction.
作者 杨月明
机构地区 辽宁省药品不良反应监测中心
出处 《中国新药杂志》 CAS CSCD 北大核心 2012年第13期1567-1570,共4页 Chinese Journal of New Drugs
关键词 普瑞巴林 Γ-氨基丁酸 临床应用 不良反应 剂量 pregabalin y-aminobutyric acid clinical application adverse reaction dosage
分类号 R969 [医药卫生—药理学]
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参考文献20

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二级参考文献81

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共引文献68

同被引文献132

引证文献18

二级引证文献43

中国新药杂志
2012年 第13期

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