摘要
目的:研究儿童糖尿病(diabetes mellitus,DM)合并自身免疫性甲状腺疾病(autoimmune thyroid disease,AI-TD)患者的临床特征,为该类疾病的治疗提供临床依据。方法:选择37例DM合并AITD儿童,其中1型糖尿病(T1DM)患者27例,2型糖尿病(T2DM)患者10例,并以32例健康体检者为对照组进行比较,分别检测甲状腺过氧化物酶抗体(TPO-Ab)、甲状腺球蛋白抗体(TG-Ab)、促甲状腺激素受体抗体(TR-Ab)的水平,同时检测糖尿病组患者的谷氨酸脱羧酶抗体(GAD-Ab);分析DM与AITD的并发情况。结果:T1DM合并AITD的患者中,桥本氏病占59.3%,Graves病占40.7%;T2DM合并AITD的患者中,桥本氏病占60.0%,Graves病占40.0%;T1DM组任一甲状腺抗体(包括TPO-Ab、TG-Ab和TR-Ab)阳性检出率为44.4%,明显高于T2DM组和对照组(P<0.05);GAD-Ab阳性的T1DM组患者任一甲状腺抗体阳性检测率为52.6%,明显高于GAD-Ab阴性的T1DM患者(P<0.05)。结论:不同类型糖尿病对于AITD的分型无明显影响,与T2DM和健康人群比较,T1DM患者更容易并发AITD,其中GAD-Ab阳性的患者并发AITD的比例要高于GAD-Ab阴性的患者。
Objective：To research the clinical characteristics of children with diabetes mellitus （DM） combined with autoimmune thyroid disease （AITD）, provide a clinical basis for treatment. Methods：A total of 37 children with DM combined with AITD were selected, including 27 children with T1DM and 10 children with T2DM; 32 healthy children receiving physical examination were selected as control group, then the results in the two groups were compared. The levels of thyroid peroxidase antibody （ TPO - Ab）, thyroglobulin antibody （ TG - Ab）, and thyrotropin receptor antibody （TR -Ab） were detected; the level of glutamic acid decarboxylase antibody （GAD -Ab） was detec- ted during the same period; the complications of DM and AITD were analyzed. Results：Among the children with T1DM combined with AI- TD, the proportions of Hashimoto~ disease and Graves~ disease were 59. 3% and 40. 7% , respectively; among the children with T2DM com- bined with AITD, the proportions of Hashimoto~ disease and Graves~ disease were 60.0% and 40.0%, respectively; the positive detection rate of TPO - Ab, TG - Ab or TR - Ab was 44.4% in T1DM group, which was significantly higher than those in T2DM group and Control group （P 〈0. 05）. The positive detection rate of TPO -Ab, TG- Ab or TR -Ab was 52. 6% in the children with positive GAD -Ab in T1DM group, which was significantly higher than that in the children with negative GAD - Ab in T1DM group （ P 〈 0.05 ）. Conclusion： Dif- ferent types of DM had no obvious impact on AITD types, compared with T2DM children and healthy children, T1DM children are more easy to occur AITD, the proportion of GAD - Ab positive children with AITD was higher than that of GAD - Ab negative children with AITD.
出处
《中国妇幼保健》
CAS
北大核心
2012年第21期3280-3282,3323,共4页
Maternal and Child Health Care of China
