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2,2′-联咪唑硝基衍生物的合成及与DNA相互作用的研究 被引量：1

Study on Synthesis of Nitroderivatives of 2,2′-Biimidazole and Their Interaction with DNA
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摘要 基于硝基咪唑类化合物有着广泛的抗微生物活性,合成了2,2′-联咪唑的单硝基NO2Hbiim和二硝基(NO2)2biim两种衍生物,通过元素分析、紫外光谱、红外光谱、热重分析对其进行了表征,并采用紫外光谱法、荧光光谱法和粘度法研究了二者与小牛胸腺DNA(ct-DNA)的相互作用。结果表明,化合物结构的共平面性对其与DNA的插入作用有较大的影响。 In view of the nitroimidazole compounds having antimicrobic activity in a wide range, two nitro- derivatives of 2,2＇-biimidazole,NOz Hbiim and （NOz）zbiim, had been synthesized and characterized by elemental analysis, UV, IR and TG-DSC. The binding of the compounds with calf thymus DNA were investigated by UV, fluorescence spectrum and viscosity measurement. The results indicated that the coplanarity of the com- pound structure had a greater impact on its insertion into DNA.
作者 杨莉宁 姚琳 余丽丽 杨黎燕 尤静
机构地区 西安医学院药学院
出处 《化学与生物工程》 CAS 2012年第7期56-59,共4页 Chemistry & Bioengineering
关键词 2 2’-联咪唑硝基衍生物 小牛胸腺DNA 构效关系 nitroderivatives of 2,2＇-biimidazole calf thymus DNA（ct-DNA） structure-activity relationship
分类号 O626.23 [理学—有机化学] O657.3 [理学—分析化学]
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参考文献18

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共引文献45

同被引文献5

  • 1胡芳红,梁洪泽,张涛,任英涛.微波促进2，2’-联咪唑的快速合成[J].宁波大学学报（理工版）,2007,20(3):373-375. 被引量：1
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  • 3咪唑类衍生物及其过渡金属配合物的设计、合成和结构表征[D].南昌大学学位论文,2007.
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  • 5王俊伟,张淑贤,田燕妮.2,2′-联咪唑合成的改进方法[J].大学化学,2009,24(2):48-50. 被引量：6

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化学与生物工程
2012年 第7期

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