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DNA甲基化在Barrett食管和食管腺癌的研究 被引量：2

DNA methylation in Barrett esophagus and esophageal adenocarcinoma
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摘要 近年来大量研究表明，肿瘤相关基因启动子区的高甲基化是引发食管腺癌的重要原因之一，并与肿瘤的分化、侵袭、转移、分期和预后等密切相关，可作为食管腺癌临床检测和治疗的新靶点。 In recent years, a large number of researches show that the tumor related gene promoter hypermethylation is an important reason of esophageal adenocarcinoma and closely associated with the differentiation, invasion, metastasis, staging and prognosis of tumors. It might be used as a new target for the clinical detection and therapy of esophageal adenocarcinoma.
作者 李波 凌志强 毛伟敏
机构地区 浙江省肿瘤医院浙江省肿瘤研究所
出处 《国际肿瘤学杂志》 CAS 2012年第6期439-442,共4页 Journal of International Oncology
关键词 DNA甲基化 BARRETT食管 食管肿瘤 腺癌 DNA methylation Barrett＇s esophagus Esophageal neoplasms Adenocarcinoma
分类号 R735.1 [医药卫生—肿瘤]
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参考文献24

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同被引文献21

  • 1王震凯,汪芳裕.DNA甲基化与肿瘤[J].医学研究生学报,2011,24(6):641-645. 被引量：15
  • 2吕斌斌,彭剑雄.DNA甲基化与基因沉默及肿瘤[J].国际检验医学杂志,2006,27(1):52-54. 被引量：12
  • 3陈合成,杨金升.基质金属蛋白酶-9在脑缺血中的作用[J].国际脑血管病杂志,2007,15(2):144-147. 被引量：15
  • 4Post WS, Coldschmidt-Clermont PJ, Wilhide CC, et al. Methylation of the estrogen receptor gene is associated with agingand atherosclerosis in the cardiovascular system. Cardiovasc Res, 1999, 43 (4) :985-991.
  • 5Hiltunen MO, Yla-Herttuala S. DNA methylation, smooth muscle cells, and atherogenesis. Arterioscler Thromb Vase Bioi, 2003 ,23 (10) : 1750-1753.
  • 6Chung S, Gebre AK, Seo J , et al. A novel role for ABCA1 generated large pre-beta migrating nascent HDL in the regulationof hepatic VLDL triglyceride secretion.] Lip id Res,2009 ,51 (4) :729-742.
  • 7Fasano T, Bocchi L, Pisciotta L, et al. Denaturing high-performance liquid chromatography in the detection of ABCA1 gene mutations in familial HDL deficiency.] Lipid Res,2007 ,46(4) :817.
  • 8Meuwese MC, de Groot E, Duivenvoorden R, et al. ACAT inhibition and progression of carotid atherosclerosis in patients with familial hypercholesterolemia. JAMA ,2009 ,301 (11): 1131-1139.
  • 9Post WS, Goldschmidt-Clermont PJ, Wilhide CC, et al. Methylation of the estrogen receptor gene is associated with agingand atherosclerosis in the cardiovascular system. Cardiovasc Res, 1999, 43 (4) :985-991.
  • 10LaukkanenMO,Mannermaa S, Hiltunen MO ,et al. Local hypomethylation in atherosclerosis found in rahbitec-sodgene. Arterioscler Thromb Vasc BioI. 1999,19(9) :2171-2178.

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国际肿瘤学杂志
2012年 第6期

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