摘要
目的探讨10%5-氨基酮戊酸光动力联合胶原蛋白贴治疗中重度痤疮的临床疗效。方法选择我院2010年1月—2011年6月收治的160例中重度痤疮,按照数字编号随机分为治疗组与对照组。治疗组80例,予10%5-氨基酮戊酸光动力联合胶原蛋白贴治疗;对照组80例,仅予10%5-氨基酮戊酸光动力治疗,8周后进行总体评估,并记录两组治疗过程中出现的不良反应。结果治疗组痊愈率50.63%,总有效率86.08%,对照组痊愈率40.51%,总有效率72.15%,两组痊愈率比较差异无统计学意义(χ2=1.29,P>0.05),总有效率比较差异有统计学意义(χ2=4.63,P<0.05)。结论 10%5-氨基酮戊酸光动力联合胶原蛋白贴治疗中重度痤疮可提高疗效,并减少不良反应。
Objective To explore the clinical efficacy of 10% 5-aminolaevulinic acid photodynamic therapy （ALA- PDT） combined with collagen dressing in the treatment of moderate to severe ache. Methods 160 patients with moderate to se- vere ache admitted during January 2010 and June 2011 in our hospital were divided into therapy group and control group （ n = 80） according to digital numbers. Patients in therapy group were given 10% ALA-PDT combined with collagen dressing, while patients in control group were only given 10% ALA- PDT. The patients＇therapeutic efficacy was evaluated after treatment for 8 weeks. Adverse effects of the two groups were also recorded in therapeutic process. Results The cure rate was 50.63% and to- tal efficacy rate was 86.08% in therapy group while the cure rate was 40.51% and total efficacy rate was 72.15% in control group. The difference between the two groups in the cure rate was not statistically significant （ X2 = 1.29, P 〉 0.05） , while the difference in total efficacy rate was statistically significant （ X2 = 4.63, P 〈 0.05）. Conclusion Photodynamic therapy with 10% 5-aminolevulinic acid combined with collagen dressing is a simple and effective treatment for moderate lo severe ache with fewer side reactions.
出处
《临床误诊误治》
2012年第7期83-85,共3页
Clinical Misdiagnosis & Mistherapy
基金
全军十二五面上课题(CWS11J204)
关键词
5-氨基酮戊酸
光化学疗法
胶原
蛋白
痤疮
寻常
Aminolevulinic acid
Photochemotherapy
Collagen
Egg white
Acne vulgaris
