摘要
目的探讨慢性阻塞性肺疾病(COPD)对非小细胞肺癌(NSCLC)预后的影响。方法收集96例确诊NSCLC患者的临床资料,通过Kaplan-Meier分析伴发或不伴发COPD的NSCLC患者的生存时间。以TNM分期为分层因素,应用COX比例风险回归模型评价年龄、性别、ECOG体能评分及COPD分级对NSCLC预后的影响。结果伴发COPD共有38例患者,占所有病例39.6%。伴发COPD的NSCLC患者生存时间8.0个月(95%CI 7.0～9.0个月)较未伴发COPD的NSCLC患者生存时间11.0个月(95%CI 9.1～12.9个月)显著缩短(P=0.009)。多因素分析结果显示:ECOG体能评分(HR=2.35,95%CI 1.21～4.56)、伴发中度(HR=2.65,95%CI 1.44～4.85)或重度以上COPD(HR=4.659,95%CI2.04～10.65)可作为NSCLC独立的预后因素。结论 COPD影响NSCLC患者的预后,是一个独立的不良预后因素,对指导NSCLC个体化治疗有着重要意义。
Objective To explore the influence of chronic obstructive pulmonary disease （COPD） on prognosis of non-small cell lung cancer （NSCLC）. Methods Ninety-six patients with cytohistologic diagnosis of NSCLC were collected. The Kaplan- Meier method was used for survival analysis of NSCLC patients. A multivariate Cox proportional hazard model, stratified by TNM stage, was used to evaluate influencing factors, such as sex, age, ECOG and COPD severity. Results COPD was pre- sent in 38 patients （39.6%）. The median survival time of comorbid COPD （95%CI 7.0-9.0 months） was lower than non-comorbid COPD （95%CI 9.1-12.9 months, P = 0.009）. Multivariate analyses identified ECOG （HR=2.35, 95%CI 1.21-4.56）, moderate COPD （HR=2.65, 95%CI 1.44-4.85）, and severe COPD （HR=4.659, 95%CI 2.04-10.65） as independent prog- nostic factors. Conclusion The presence of COPD affects the prognostic outcome of patients with NSCLC and remains as an independent predictor of poor outcome, which can provide individualized treatment strategy for NSCLC patients.
出处
《中国现代医生》
2012年第20期41-42,45,共3页
China Modern Doctor
关键词
非小细胞肺癌
慢性阻塞性肺疾病
预后
Non-small cell lung cancer
Chronic obstructive pulmonary disease
Prognosis
