摘要
目的回顾性研究鼠神经生长因子在HIV/AIDS合并隐球菌性脑膜炎中的治疗作用。方法收集北京佑安医院2010年1月至2011年12月收治的26例HIV/AIDS合并隐球菌性脑膜炎患者的临床资料,其中鼠神经生长因子治疗组16例,对照组10例,回顾性分析两组患者的临床特点。结果 73.1%(19例)的患者为31～38岁,男性18例(69.2%),发病时CD4<100个/μl者占76.9%(20例),从发现HIV阳性到发病时间在1年内者占57.7%(15例),入院时两组间在生命体征及脑脊液指标方面差异无统计学意义。经治疗后,鼠神经生长因子治疗组患者除2人未愈外均好转/痊愈出院,而对照组中7例好转/痊愈,2例未愈,1例死亡。治疗组抽搐、视乳头水肿和肌无力症状缓解时间与对照组比较有明显缩短(P值分别为0.025、0.013、0.032)。两组平均住院天数分别为(61.1±9.1)d和(70.0±11.1)d,差异无统计学意义。结论鼠神经生长因子对于HIV/AIDS合并隐球菌性脑膜炎的治疗可能有辅助作用。
Objective To summarize the clinical features of cryptococcal meningitis-complicated HIV infections treated with mouse nerve growth factor（mNGF）.Methods A retrospective analysis was performed to analyze the clinical data from 26 patients of HIV infection complicated with cryptococcal meningitis（16 with and 10 without mNGF treatment） in Beijing You′an Hospital from January 2010 to December 2011.Results Among 26 enrolled patients,19（73.1%） were 31-38 years old and 18（69.2%） were male;CD4100 was detected in 20（76.9%） patients;15（57.7%） were diagnosed cryptococcal meningitis within one year following their first diagnosis of HIV infection.There were no significant differences in vital signs and cerebrospinal fluid（CSF） markers at admissions to the hospital between the mNGF-treated and untreated groups.Among 16 patients treated with mNGF,clinical improvement was clearly seen in 15 patients and cured;while in the group of 10 patients without mFNG treatment,only 7 were improved/cured,3 without improvement including one died.Symptoms such as twitching,papilledema and muscle weakness were relieved sooner in mNGF-treated patients compared to that in the untreated group（P=0.025,0.013 and 0.032,respectively）.The average hospitalized days of mNGF-treated and untreated patients were 61.1±9.1 and 70.0±11.1,respectively（P0.05）.Conclusions mNGF may be beneficial to patients of HIV infection complicated with cryptococcal meningitis.
出处
《中国病毒病杂志》
CAS
2012年第4期277-280,共4页
Chinese Journal of Viral Diseases
基金
北京市属高等学校人才强教计划资助项目(PHR201007112)
艾滋病研究北京市重点实验室项目(BZ0089)
