摘要
目的研究中晚期子宫颈癌根治性同步放化疗后晚期不良反应,探讨可能诱发晚期不良反应的易感因素及早期防治方法。方法 回顾性分析398例行根治性同步放化疗中晚期子宫颈癌病例以及152例单纯行根治性放疗的中晚期子宫颈癌病例,对比分析两组病例晚期不良反应发生率,回顾性分析严重晚期不良反应可能的易感因素。结果 同步放化疗组放射性肠炎及放射性膀胱炎发生率分别为25.1%、10.5%,单纯放疗组放射性肠炎及放射性膀胱炎发生率分别为12.5%、3.3%,两组差异有统计学意义(P<0.05),生殖系统、皮肤、皮下组织等方面比较差异无统计学意义(P>0.05)。结论 同步放化疗作为目前不能手术的中晚期子宫颈癌标准治疗方法,有一定的晚期不良反应,临床工作中应针对易感因素行早期防治,降低晚期不良反应的发生率,提高患者生存质量。
Objective To assess the adverse reactions of concurrent chemoradiotherapy in patients with intermediate-advanced cervical cancer. Methods Clinical data of 398 patients with intermediate-advanced cervical cancer receiving concurrent chemoradiotherapy and 152 patients receiving radical radiotherapy alone were retrospectively analyzed. The adverse reactions of two groups were compared and the risk factors were analyzed. Results The radiation cystitis and radiation enteritis rates in chemoradiotherapy group were higher than those in radiotherapy group （25.1% vs 12.5 %, 10.5% vs 3.3 %, respectively;both P 〈 0.05 ）. There were no significant differences in adverse reactions of reproductive system, skin and subcutaneous tissue （ P 〉 0. 05 ）. Conclusion Compared to radiotherapy alone, concurrent chemoradiotherapy for inoperable patients with intermediate-advanced cervical cancer has higher adverse response rate. It is necessary to take early prevention to reduce the adverse response rate.
出处
《实用肿瘤杂志》
CAS
2012年第4期378-381,共4页
Journal of Practical Oncology
关键词
宫颈肿瘤/放射疗法
宫颈肿瘤/药物疗法
综合疗法
uterine cervical neoplasms/radiotherapy
uterine cervical neoplasms/drug therapy
combined modality therapy
