摘要
目的:探讨经尿道等离子电切联合内分泌治疗伴膀胱出口梗阻(BOO)晚期前列腺癌(PCa)的临床疗效。方法:对15例伴BOO的晚期PCa患者行经尿道等离子电切加双侧睾丸切除术和口服氟他胺或吡卡鲁胺的内分泌治疗。结果:15例患者术后下尿路症状均明显减轻,术后12月,国际前列腺症状评分(IPSS)由术前(18-30)分降至(2-12)分(P<0.01)、最大尿流率(Qmax)由术前(9.1±0.5)ml/s增至(19.2±2.2)ml/s(P<0.01)、残余尿量(RV)由术前(220.3±16.5)ml降至(42.4±4.3)ml(P<0.01),前列腺特异性抗原(PSA)由术前(130.8±11.7)ng/ml降至(9.8±0.9)ng/ml(P<0.01)。所有患者均随访至少24月,无死亡病例。结论:晚期伴BOO的PCa患者,经尿道等离子电切联合内分泌治疗是一种安全、有效的姑息性治疗方法。
Objective：To explore clinical effect of transurethral plasmaknetic resection combined with endocrino- therapy for treating advanced prostate cancer accompanied by bladder outlet obstruction （BOO）. Methods：Fifteen ca- ses with advanced prostate cancer accompanied with BOO were treated with transurethral plasmaknetic resection com- bined with endoerinotherapy（ bilateral orehiectomy and oral anti -androgen drugs）. Results：Subjective symptoms and objective signs were all improved and BOO was relieved, after 12 months, the international prostate symptom score （IPSS） and maximum urine flow rate （Qmax）, residue urine volum （RV）, serum prostate - specific antigen （PSA） were improved significantly （ 18 - 30 score versus 2 - 12 score,9.1±0.5ml/s versus 19.2 ±2.2ml/s, 220.3 ± 16.5ml versus 42.4± 4.3ml, 130.8±11.7ng/ml versus 9.8 ± 0.9 ng/ml, P 〈 0.01 ）. Conclusion： For the patients with advanced prostate cancer accompanied by BOO, transurethral plasmaknetic resection combined with en- docrinotherapy is a safe and effective measure.
出处
《现代肿瘤医学》
CAS
2012年第8期1671-1672,共2页
Journal of Modern Oncology
