摘要
Versican是蛋白聚糖家族之一,其表达水平增高与许多肿瘤的不良预后有关。肿瘤的类型不同,其表达部位也不同,可以表达在肿瘤细胞本身,也可以表达在肿瘤周围的间质中。Versican在细胞黏附、增殖、迁移和血管生成中都起作用,这些特点与肿瘤的侵袭和转移有关。这些功能特点有赖于Versican的中间氨基葡聚糖结合区以及两末端的球状区域与许多细胞外基质和细胞表面成分的相互作用。本文对最近发现的调控Versican表达的机制以及它在肿瘤侵袭和转移中的生物学作用作一综述。
Versican is one number of the proteoglycan family, it is strongly associated with poor outcome for many different cancers. Depending on the cancer type, Versican is expressed by either the cancer cells themselves or by stromal cells surrounding the tumor. Versican plays diverse roles in cell adhesion, proliferation, migration and angio- genesis, all features of invasion and metastasis. These wide ranging functions have been attributed to the central gly- cosaminoglycan binding region of Versican, and to the N - （ G1 ） and C - （ G3 ） terminal globular domains which collectively interact with a large number of extracellular matrix and cell surface structural components. Here we re- view the recently identified mechanisms responsible for the regulation of Versican expression and the biological roles that Versican plays in cancer invasion and metastasis.
出处
《现代肿瘤医学》
CAS
2012年第8期1735-1739,共5页
Journal of Modern Oncology
基金
黑龙江省自然科学基金项目(编号:D201103)
