培美曲赛联合方案一线治疗IIIB／Ⅳ期肺腺癌的临床观察被引量：2

Clinical observation on pemetrexed combination regimen as first-line treatment for IIIB/IV lung adenocarcinoma

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摘要目的观察培美曲赛联合铂类（顺铂、卡铂或奈达铂）一线治疗IIIB／IV期肺腺癌患者的近期疗效及毒副反应。方法20例初治IIIB／IV期肺腺癌接受培美曲塞联合铂类化疗，接受至少2个周期化疗后评价临床疗效和毒副反应。结果20例中完全缓解（CR）0例，部分缓解（PR）5例，病情稳定（SD）12例，病情进展（PD）3例，总有效率为（CR＋PR）25％，总疾病控制率为（CR＋PR＋SD）85％。主要毒副反应为血液学毒性和胃肠道反应。结论培美曲赛联合铂类一线治疗IIIB／IV期肺腺癌有较好的疾病控制率，毒副反应可耐受。 Objective To observe the clinical efficacy and toxicities of pemetrexed combined with platinum as the first-line regimen for IIIB/IV lung adenocarcinoma. Methods 20 patients with IIIB/IV lung adenocarcinoma received pemetrexed combined with platinum chemotherapy as the first-line treatment, the clinical efficacy and toxicities were evaluated after at least 2 cycles of chemotherapy. Results Among all 20 cases, no case with CR, 5 cases with PR, 12 cases with SD, B cases with PD were found, the total effective rate was 25% and the total disease control rate was 85%. The main toxicities were bone marrow depression and gastrointestinal reaction. Conclusion The pemetrexed combined with platinum as the first-line regimen in the treatment for IIIB/IV lung adenocarcinoma has reliable efficacy and less toxicities.

作者瞿燕春曲鑫李勇白建平刘译鸿刘丽荣张海波

机构地区广东省中医院肿瘤科

出处《国际医药卫生导报》 2012年第14期2040-2042,共3页 International Medicine and Health Guidance News

关键词肺腺癌培美曲赛一线治疗 Lung adenocarcinoma Pemetrexed First-line treatment

分类号 R734.2 [医药卫生—肿瘤]

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