摘要
目的观察枸橼酸氯米芬抵抗的多囊卵巢综合征患者使用来曲唑促排卵的疗效。方法22例对枸橼酸氯米芬抵抗的多囊卵巢综合征患者服用来曲唑，观察记录卵泡发育、人绒毛膜促性腺激素（HCG）注射日子宫内膜厚度、血清雌二醇（E2）水平和宫颈黏液评分等指标，对来曲唑和枸橼酸氯米芬的疗效进行比较。结果对于枸橼酸氯米芬抵抗的患者使用来曲唑治疗，有促排卵效果，HCG注射13子宫内膜厚度增加、血清E2水平下降、宫颈黏液评分增加，差异有统计学意义（P〈0．01）。结论来曲唑用于枸橼酸氯米芬抵抗的多囊卵巢综合征患者促排卵有一定疗效。
Ojective To investigate the therapeutic effects of letrozole on polycystic ovary syndrome （PCOS） with resistance to clomiphene citrate （CC）. Methods 22 PCOS patients with resistance to CC received oral administration of letrozole. The follicular development, endometrial thickness at the date of HCG injection, serum E2 level, and the cervical mucus score were observed. The therapeutic effects between letrozole and CC were compared. Results Letrozole had ovulation induction effect in PCOS patients with resistance to CC. Compared with patients who received CC treatment, the endometrial thickness at the date of HCG injection was increased, serum E2 level was decreased, and the cervical mucus score was increased in palients who received letrozole treatment, with statistically significant differences （P 〈0.01 ）. Conclusion Oral administration of letrozole is effective in the induction of ovulation for PCOS patients with resistance to CC.
出处
《徐州医学院学报》
CAS
2012年第6期408-410,共3页
Acta Academiae Medicinae Xuzhou
关键词
来曲唑
枸橼酸氯米芬
多囊卵巢综合征
排卵
letrozole
clomiphene citrate
polycystic ovary syndrome
ovulation
