摘要
采用反相蒸发法制备 5 氟尿嘧啶脂质体制剂 .结合冻融法 ,可使 5 氟尿嘧啶的包封率达(45 31± 0 2 0 85 ) % .离心加速实验和 ζ电位的测定进一步验证了冻融法可使脂质体稳定性提高 .
FU liposome was prepared by the reverse evaporating method.Then the entrapment reached 4331% by freezethawing 5FU liposome several times.The centrifugal accelaration experiment and the measurement of ζ potential proved that the stability of the liposome could be ameliorated.
出处
《沈阳药科大学学报》
CAS
CSCD
2000年第2期87-89,共3页
Journal of Shenyang Pharmaceutical University
基金
国家自然科学基金资助项目 !No.3 9570 84 3
关键词
5-氟尿嘧啶
脂质体
冻封率
稳定性
5-FU liposome
freezethawing method
entrapment
stability
