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hTERC基因、C-MYC基因表达在宫颈病变中的意义 被引量：1

Significance of Expression of hTERC Gene and C-MYC Gene in Cervical Lesions
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摘要 收集我院妇科门诊体检及就诊患者的宫颈脱落细胞,对其进行荧光原位杂交检测hTERC基因、C-MYC基因,最终进行病理学检查确诊。结果在正常宫颈中hTERC基因、C-MYC基因未出现异常扩增,CIN1中其扩增率分别为21.74%及17.39%,CIN2中为57.90%及52.63%,CIN3中为85.71%及90.48%,浸润性宫颈癌的扩增率达100%。
作者 刘聃 魏力
机构地区 中国医科大学附属第四医院妇科
出处 《现代诊断与治疗》 CAS 2012年第4期300-301,共2页 Modern Diagnosis and Treatment
基金 辽宁省科技攻关计划项目(2008225010-11) 沈阳市科学技术计划项目(F10-149-9-37)
关键词 宫颈癌 宫颈上皮内瘤变 人端粒酶基因 C-MYC基因
分类号 R737.33 [医药卫生—肿瘤]
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参考文献4

  • 1Caraway NP,Khanna A,Dawlett M,et al.Gain of the 3q26 region in cer-vicovaginal liquid-based pap preparations is associated with squamous in-traepithelial lesions and squamous cell carcinoma[J].Gynecol Oncol,2008,110:37-42.
  • 2Andersso S,Wallin KL,Hellstrom AC,et al.Frequent gain of the humantelomerase gene TERC at 3q26 in cervical adenocarcinomas[J].Br JCancer,2006,95:311-338.
  • 3Tsuyoshi I,Masatoshi Y,Mamora O,et al.Detection of human papillomavirus genome and analysis of expression c-myc and Ha-ras oncogenes ininvasive cervical carcinomas[J].Gynecol Oncol,1992,46:298.
  • 4Sonia A,Pavani S,et al.Detection of Genomic Amplification of the Hu-man Telomerase Gene TERC,a Potential Marker for Triage of Womenwith HPV-Positive,Abnormal Pap Smears[J].Am J Pathol,2009,175(5):1831-1847.

同被引文献15

  • 1Rashid S, Khaund A, Murray LS, et al. The effects of uterine ar- tery embolisati-on and surgical treatment on ovarian function in women with uterine fibroids [ J ], B JOG, 2010,117 ( 8 ) :985 -989.
  • 2Katki HA, Kinney WK, Fetterman B, et al. Cervical cancer risk for women un-dergoing concurrent testing for human papillomavirus and cervical cytology:a p-opulation-based study in routine clinical practice [ J ]. Lancet Oneol, 2011,12 ( 7 ) :663-672.
  • 3Andersson S, Sowjanya P, Wangsa D, et al. Detection of genomic aplificationof the haman telomerase gene TERC, a potential mark- er for triage of women with HPV-positive, abnormal Pap smears [J]. Am J Pathol, 2009,175($) :1531-1S47.
  • 4Nafisawa-Saito M, Handa K, Yugawa T. HPV16 E6-mediated sta- bilization of ErbB2 in neoplastic transformation of human cervical keratinoeytes[ J]. Oncogene, 2007,26 ( 21 ) :2988-2996.
  • 5Kuglik P, Kasikova K, Smetana J, et al. Molecular cytogenetic an- alyses of hT-ERC(3q26) and MYC(8q24) genes amplifications in correlation with ongeneni human papillomavirus infection in Czech patients with cervical intraepithelial n-eoplasia and cervical carci- nomas[J]. Neoplasma, 2015,62(1) :130-139.
  • 6Li T, Tang L, Bian D, et al. Detection of hTERC and c-myc genes in cervical epithelial exfoliated cells for cervical cancer screening [J]. Int J Mol Med, 2014,33(5) :1289-1297.
  • 7江维,李隆玉.宫颈上皮内瘤变Ⅰ级的自然转归与随访观察[J].实用癌症杂志,2009,24(2):188-190. 被引量：11
  • 8荣晅,乌兰娜,高积勇,周艳秋,王纯,吴瑞芳.宫颈上皮内瘤变Ⅰ级的自然转归研究[J].现代妇产科进展,2012,21(5):365-368. 被引量：11
  • 9张蕾,赵计端.液基薄层细胞学结合TBS系统对宫颈癌筛查的临床意义[J].现代预防医学,2013,40(1):35-37. 被引量：12
  • 10李凌,江维,曾四元,李隆玉.荧光原位杂交技术检测hTERC基因预测宫颈上皮内瘤样病变1级自然转归的前瞻性研究[J].中国肿瘤临床,2013,40(1):25-28. 被引量：4

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现代诊断与治疗
2012年 第4期

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