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内质网应激与耳聋 被引量:2

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摘要 内质网(endoplasmic reticulum,ER)是真核细胞所特有的亚细胞器结构.参与内分泌性蛋白及膜蛋白翻译后加工修饰、正确折叠和新生蛋白的转运过程。然而,多种生理、生化以及一系列的细胞毒因素,如基因突变或机体状态的改变包括缺血、缺氧、营养不足、病毒感染、钙平衡失调等各种内质网刺激因子均可干扰蛋白质的合成,
出处 《中国听力语言康复科学杂志》 2012年第4期270-273,共4页 Chinese Scientific Journal of Hearing and Speech Rehabilitation
基金 全军十一五项目归国人员课题(06H048) 全军十二五面上项目(11MS013):国家自然科学基金面上项目青年基金(30700936) 中国人民解放军第309医院院内基金(LCB08MS12、309-09-03) 国家973计划重大科学研究计划干细胞项目(2012CB967900):国家973计划重大科学问题导向项目(2011CBA01000) 国家863计划专题项目(2007AA022150):国家自然科学基金重点项目(30730040)
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