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GSK3β在胃癌中的表达 被引量：1

Expression of GSK3β in gastric cancer tissues
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摘要 目的通过观察糖原合成酶激酶-3β(Glycogen synthase kinase-3β,GSK-3β)蛋白在胃癌组织中的表达变化,探讨GSK3β在胃癌中的临床意义。方法应用免疫组织化学(IHC)SP法检测45例胃癌组织中GSK3β蛋白的表达变化。结果 GSK-3β蛋白在胃癌中的阳性率为40.00%,明显低于正常组织(P<0.05)。GSK-3β的蛋白改变与胃癌的TNM分期、分化程度以及淋巴结转移有关联(P<0.05)。结论 GSK-3β的降低参与了胃癌的发生,GSK-3β的检测对评估预后具有一定参考价值。 Objective To investigate the expression ofSTAT3,Survivin andVEGF in gastric cancer and its correlation with the clinicopathological feature.Methods The protein expression level of GSK3βwas detected by immunohistochemistry（IHC） with Strep tavidin-Peroxidase（SP） in 45 case of gastric cancer tissues.Results The result showed that the positive expression rate of GSK3βin carcinoma was lower than that in normal tissues（P〈0.05）;The expression of GSK3βwas correlated with phase TNM,differentiated（P〈0.05） and lymphnode memtastasis（P〈0.05）.Conclusions GSK3β low expression play an important role in the pathogenesis of gastric cancer.
作者 冯锦辉 杨伟珍 刘海鹏 陈盛强
机构地区 广东省广州市番禺区石碁人民医院 广东省广州市番禺区沙湾人民医院 广州医学院第二附属医院
出处 《齐齐哈尔医学院学报》 2012年第12期1570-1571,共2页 Journal of Qiqihar Medical University
基金 番禺区科技项目:2010-z-109-1
关键词 胃癌 GSK3Β 浸润 转移 Gastric cancer GSK3β Infiltration Metastasis
分类号 R811 [医药卫生—放射医学]
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参考文献11

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二级参考文献10

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共引文献9

同被引文献9

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齐齐哈尔医学院学报
2012年 第12期

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