摘要
目的分析小剂量米非司酮治疗围绝经期功能失调性子宫出血的治疗效果。方法选取本院就诊的功能失调性子宫出血的78例围绝经期妇女病例进行回顾性分析,米非司酮组40例与去氧孕烯炔雌醇组38例,观察并对照两组患者的疗效及不良反应。结果米非司酮组患者的月经情况改善优于去氧孕烯炔雌醇组。2组患者治疗后性激素水平除促卵泡激素(FSH)、黄体生成素(LH)、催乳激素(PRL)与治疗前相比无显著差异外,其他激素水平、子宫内膜厚度以及与平均血红蛋白治疗前相比均明显下降。米非司酮组与去氧孕烯炔雌醇组相比治疗后子宫内膜厚度降低更为明显,孕酮(P)、雌二醇(E2)水平以及平均血红蛋白升高更为明显。结论小剂量米非司酮可以抑制子宫内膜增生,促进绝经,在治疗围绝经期功能失调性子宫出血方面效果令人满意,且无明显肝肾毒性,安全有效,值得推广。
Objective To explore the efficacy of low-dose mifepristone combined with desogestrel and ethinyl estradio in the treatment of perimenopausal dysfunctional uterine bleeding.Methods The clinical data of 78 perimenopausal women with dysfunctional uterine bleeding in our hospital were retrospectively analyzed.They were divided into mifepristone group（n=40） and desogestrel and ethinyl estradiol group（n=38）.The clinical efficacy and adverse events in both groups were observed and compared.Results The menstrual improvement was better in mifepristone group than in desogestrel and ethinyl estradiol group.After treatment,sex hormone levels such as follicle stimulating hormone（FSH）,luteinizing hormone（LH）,and prolactin（PRL） did not have significant changes.But other hormone levels,endometrial thickness and average hemoglobin were significantly decreased.Compared with desogestrel and ethinyl estradiol group,endometrial thickness decreased more significantly in mifepristone group,but progesterone（P）,estradiol（E2） levels and average hemoglobin increased more significantly.Conclusion The low-dose mifepristone inhibits endometrial proliferation and promotes menopause.It can achieve desirable outcomes in the treatment of perimenopausal dysfunctional uterine bleeding with no obvious hepatorenal toxicity.It is safe and worthy of wider application.
出处
《实用临床医药杂志》
CAS
2012年第11期105-107,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11220050)
