摘要
目的观察短期大剂量益母草对大鼠肾脏的影响。方法取益母草煎液,以60g/(kg d)剂量给大鼠连续灌胃14天,给药后第8天、15天取大鼠尿、血和肾组织;检测尿N-乙酰-β-葡萄糖苷酶(NAG)、尿β2-微球蛋白(β2-MG)、尿蛋白(Upro)、血Cr、BUN等相关指标,并观察肾脏形态组织学变化。结果给药1周和2周后尿NAG、β2-MG、Upro及血BUN、Cr与对照组比较无显著性差异(P>0.05);大鼠肾组织未见明显病理改变。结论益母草在短时间内大剂量使用对大鼠肾脏未造成显著毒副作用。
Objective To observe the effect on the kidney in rats after taking high dose of the Herba Leonuri for a short time. Methods Herba Leonuri decoction was administered intragastrically to rats consecutively at the dose of 60g/ （kg.d） for 14 days. At the eighth day and fifteenth day, detect the urine NAG, β2-MG, Upro and blood Cr, BUN etc, and observe the pathological examination of kidney tissue. Results The Herba Leonuri cannot induce the content of urine NAG, β2-MG, Upro and blood Cr, BUN after taking high dose of the Herba Leonuri for two weeks, and pathological examination of kidney tissue show no significant injury after two weeks. Conclusion The short-term administration of the Herba leonuri to rats cannot induce obvious kidney injury.
出处
《中国医药指南》
2012年第19期8-9,共2页
Guide of China Medicine
关键词
益母草
大剂量
毒性
The Herba Leonuri
High dose
Toxicity
