期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

替莫唑胺治疗胶质母细胞瘤的近期不良反应观察 被引量：7

原文传递
导出
摘要 胶质母细胞瘤是常见的原发性中枢神经系统恶性肿瘤，其治疗方式是以包括手术、放疗及化疗的综合治疗。尽管经过数十年的临床努力，但患此恶性肿瘤的患者预后仍较差，生存期约为9—12个月。替莫唑胺（TMZ）作为一种新型的口服二代烷化剂类化疗药，在中枢神经系统可达到有效的药物浓度，是一种理想的脑胶质瘤化疗药物。
作者 甘燕玲 杨玉山 陈步东 张春智
机构地区 天津市环湖医院神经外科七病区 天津市环湖医院放疗科
出处 《中华神经外科杂志》 CSCD 北大核心 2012年第7期693-695,共3页 Chinese Journal of Neurosurgery
关键词 胶质母细胞瘤 替莫唑胺 治疗方式 中枢神经系统恶性肿瘤 不良反应 化疗药物 综合治疗 烷化剂类
分类号 R739.4 [医药卫生—肿瘤]
  • 相关文献

参考文献15

  • 1Zhang CZ, Zhang JX, Zhang AL, et al. MiR - 221 and miR -222 target PUMA to induce cell survival in glioblastoma. Mol Cancer,2010,9:229.
  • 2Balducci M, D' Agostino GR, Manferida S, et al. Radiotherapy and concomitant temozolomide during the first and last weeks in high grade gliomas : long - term analysis of a phase Ⅱ study. J Neuroonco1,2010,97:95-100.
  • 3Stupp R, Gander M,Leyvraz S,et al. Current and future developments in the use of temozolomide for the treatment of braintumours. Lancet Onco1,2001,2 :552-560.
  • 4Koukourakis GV, Kouloulias V, Zacharias G, et al. Temozolomide with radiation therapy in high grade brain gliomas: pharmaceuticals considerations and efficacy ; a review article. Molecules ,2009,14 : 1561-1577.
  • 5Stupp R, Mason WP, van den Bent MJ, et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med ,2005,352:987-996.
  • 6Stupp R, Hegi ME, Mason WP, et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase Ⅲ study:5 - year analysis of the EORTC - NCIC trial. Lancet Oncol, 2009, 10:459-466.
  • 7Trivedi RN, Almeida KH, Fornsaglio JL, et al. The role of base excision repair in the sensitivity and resistance to temozolomide - mediated cell death. Cancer Res ,2005,65:6394-6400.
  • 8Viola G, Cecconet L, Leszl A,et al. Pyrrolotetrazinones deaza-analogues of temozolomide induce apoptosis in Jurkat cell line: involvement of tubulin polymerization inhibition. Cancer Chemother Pharmaco1,2009,64 : 1235-1251.
  • 9Oh J, Kutas GJ, Davey P, et al. Aplastic anemia with concurrent temozolomide treatment in a patient with glioblastoma multiforme. Curr Onco1,2010,17 : 124-126.
  • 10Natelson EA, Pyatt D. Temozolomide - induced myelodysplasia. Adv Hematol,2010 ,2010 :760402.

二级参考文献19

  • 1王能江,陈坚.原发性脑胶质瘤术后替莫唑胺化疗的临床观察[J].中华神经医学杂志,2007,6(5):500-502. 被引量：5
  • 2Zhang C,Zhang J,Zhang A,et al.MiR-221 and miR-222 target PUMA to induce Cell survival in glioblastoma[.J]. Molecular Cancer,2010,9:229.
  • 3Balducci M,D'Agostino GP Manfrida S,et al.Radiotherapy and concomitant temozolomide during the first and last weeks in high grade gliomas: long-term analysis of a phase Ⅱ study[J].Neuro-Oncol,2010,97(1):95-100.
  • 4Laperriere N,Zuraw L,Caimcross G.Radiotherapy for newly diagnosed malignant glioma in adults: a systematic review[J].Radiother Oncol,2002,64(3):259-273.
  • 5Grossman SA,O'Neill A,Grunnet M,et al.Phase Ⅲ study comparing three cycles of infusional carmustine and cisplatin followed by radiation therapy with radiation therapy and concurrent carmustine in patients with mewly diagnosed supratantorial glioblastoma multiforme: Eastern Cooperative Oncolgy Group Trial 2394[J].Clin Oncol,2003,21(8):1485-1491.
  • 6Baker SD,Wirth M,Statkevich P,et al.Absorption,metabolism,and excretion of 14C-temozolonide following oral administration to patients with advanced cancer[J].Clin Cancer Res,1999,5(2):309-317.
  • 7Trivedi RN,Almeida KH,Fornsaglio JL,et al.The role of base excision repair in the sensitivity and resistance to temozolomide-mediated cell death[J].Cancer Res,2005,65(14):6394-6400.
  • 8Stupp R,Mason WP,van den Bent MJ,et al.Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase Ⅲ study: 5-year analysis of the EORTC-NCIC trial[J].Lancet Oncol,2009,10(5):459-66.
  • 9Theeler B J,Groves MD.High-grade gliomas[J].Curt Treat Options Neurol,2011,13(4):386-399.
  • 10Stupp R, Hegi ME, Gilbert MR, et al. Chemoradiotherapy in malignant glioma: standard of care and future directions [J]. Clin Oncl, 2007, 25(26): 4127

共引文献15

同被引文献58

引证文献7

二级引证文献6

中华神经外科杂志
2012年 第7期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部