摘要
目的:探讨米非司酮治疗子宫内膜异位症(EMs)术后白细胞介素-6(IL-6)、肿瘤坏死因子-a(TNF-a)水平的变化情况。方法:EMs术后患者108例随机分为米非司酮治疗组和对照组(未用药),每组54例,另选择健康体检者52例作为正常组,采用ELISA检测正常组及两组患者术前、术后3d、术后12周IL-6及TNF-a水平,并进行比较。结果:术前不同分期(I～Ⅱ期、Ⅲ～Ⅳ期)EMs患者及米非司酮治疗组、对照组IL-6及TNF-a水平均明显高于正常组(P均<0.01),术后与正常组无明显差异(P均>0.05);两组术后3d、12周IL-6、TNF-a水平与术前相比差异有统计学意义(P均<0.01),米非司酮治疗组术后12周IL-6、TNF-a水平低于对照组,但差异无统计学意义(P均>0.05);术前、后IL-6与TNF-a有明显相关性(P<0.05)。结论:EMs术后应给予药物治疗,IL-6及TNF-a水平可用于监测EMs治疗效果,也可作为判断EMs早期复发的指标。
Objective： To investigate the influence of mifepristone on IL-6 and TNF level in patients with endometriosis after undergoing surgery. Methods： A total of 108 patients with endometriosis that underwent treatment were randomly divided into treatment group and control group with 54 cases in each group . Fifty-two healthy volunteers were also enrolled as normal control group. IL-6 and TNF level before undergoing surgery, 3 days and 12 weeks after undergoing treatment were detected with ELISA and compared among the three groups. Results：Before undergoing surgery, IL-6 and TNF levels in the study group （was given mifepristone） and control group were significant higher than that in the normal control group （P all d0.05）. But after undergoing surgery, no significant difference in IL--6 and TNF levels were observed. Three days and 12 weeks after undergoing surgery, IL-6 and TNF level; were significantly different from that before the surgery （P〈0.01）. After mifepristone treatment for 12 weeks, the IL-6 and TNF levels in treatment group was significant lower than that in the control group, correlation between IL-6 and TNF levels were observed. Conclusions. Drug treatment is necessary for patients undergoing Ems, IL-6 and TNF - EM levels can be used for monitoring treatment efficacy of Ems, and prediction of early recurrence.
出处
《海南医学院学报》
CAS
2012年第9期1239-1241,共3页
Journal of Hainan Medical University
基金
中国高校医学期刊临床专项资金项目(112210298)~~
