摘要
目的探讨AIDS患者淋巴结结构改变与CD4+T细胞的关系。方法 53例AIDS合并表浅淋巴结肿大患者均给予抗反转录病毒治疗(ART),并进行淋巴结组织病理检查,根据淋巴结病理结果将患者分为早期组24例和晚期组29例,检测两组ART前、ART后3个月、6个月、9个月、12个月CD4+T细胞计数,比较两组患者CD4+T细胞变化情况。结果治疗前CD4+T细胞计数<50个/μl早期组3例,晚期组24例;CD4+T细胞计数50～100个/μl早期组7例,晚期组5例;CD4+T>100个/μl均是早期组。早期组治疗前CD4+T细胞计数高于晚期组(P<0.01)。治疗后两组CD4+T细胞计数较治疗前均显著提高(P<0.01),两组治疗后3个月、6个月、9个月、12个月的CD4+T细胞计数比较差异均无统计学意义(P>0.05)。结论 AIDS患者CD4+T细胞水平可能与其淋巴结结构改变有关,但患者淋巴结结构改变可能并不影响其ART后的免疫重建。
Objective To explore the relationship of structure change of lymph node and CIM ＋ T cells in patients with acquired immunedeficiency syndrome （AIDS）. Methods Fifty three AIDS patients with superficial lymphadenectasis were treated with antiretroviral therapy （ART）, and received histopathologic examination of lymph nodes. All the patients were divided into the early group （24 cases） and the late group （29 cases） based on the pathology of lymph nodes. CIM ＋T cell count of all the patients were detected before ART,3 months,6 months,9 months,and 12 months after ART,respectively. The changes of CIM ＋T cell count were compared between the two groups. Results Before ART, there were 3 cases of CIM＋T lymphocyte count 〈 50/μl in the early group while 24 cases in the late group; Seven cases of CD4 ＋ T lymphocyte count of 50 - 100/μl in the early group while 5 cases in the late group. All of the cases of CIM ＋ T lymphocyte count 〉 100/μl were in the early group. The CIM ＋ T cell count in the early group before treatment was significantly higher than that in the late group（ P 〈 0.01 ）. The CIM ＋T cell count increased significantly in both groups after treatment（P 〈0.01 ）. There were no significant difference in CIM ＋T cell count after the 3-,6-, 9- and 12-month ART between the two groups（P 〉 0.05 ）. Conclusion The structure change of lymph nodes may be correlated with the level of CIM＋T cells in AIDS patients, but don＇t affect the immune reconstruct after ART.
出处
《广西医学》
CAS
2012年第8期984-986,共3页
Guangxi Medical Journal
基金
广西南宁市科学研究与技术开发计划
创新计划项目科研课题(201003047C-1)
