摘要
目的研究131碘(131I)治疗分化型甲状腺癌引起唾液腺损伤的评估方法,以及有效预防或减轻131I对唾液腺损伤的干预措施。方法将60例接受131I治疗的分化型甲状腺癌患者分为两组,观察组和对照组各30例。观察组采取综合干预方法,在治疗期间大量饮用酸性饮料,休息时行自我暗示疗法;对照组治疗期间口含维生素C片并大量饮水。通过问卷调查评估患者口干症状、口干程度,应用99m锝(99mTcO4-)唾液腺动态显像评估131I不同累计剂量唾液腺功能损伤程度,对两组口干症状、程度和唾液腺功能损伤程度进行比较。结果随着131I治疗累计剂量的增加,两组口干症状、程度和唾液腺受损率也明显增加,两组口干症状、程度和唾液腺功能损伤程度的差异无统计学意义。结论分化型甲状腺癌患者在131I治疗期间,采取综合干预措施与口含维生素C片的方法在保护患者唾液腺功能方面效果相似,综合干预措施可以替代口含维生素C片。
Objective To determine the assessment methods to salivary gland damage caused by ^131iodine radiotherapy in patients with differentiated thyroid cancer,and to evaluate the effect of intervention measures on salivary gland damage. Methods Sixty patients with differentiated thyroid cancer receiving ^131iodine radiotherapy were assigned to two groups. The patients in the experimental group received comprehensive intervention measures including intake of acidic drinks and auto-suggestion during rest. The patients in the control group administered oral vitamin C and drank plenty of water. The symptom of dry mouth and the degree of salivary gland damage were measured and compared between the two groups. Results With the increase of ^131I cumulative dose,the rate and degree of dry mouth symptom and the degree of salivary gland damage increased significantly in both groups. There was no significant difference in the symptom of dry mouth and the degree of salivary gland damage be- tween the two groups. Conclusion The effect of comprehensive intervention measures is comparable to oral vitamin C on re- ducing the symptom of dry mouth and salivary gland damage.
出处
《中华护理杂志》
CSCD
北大核心
2012年第8期706-709,共4页
Chinese Journal of Nursing
基金
2010年度安徽省科技厅科技计划项目(编号:10021303035)
关键词
甲状腺肿瘤
放射疗法
碘
辐射损伤
唾液腺损伤
Thyroid Neoplasms
Radiotherapy
Iodine
Radiation Injuries
Salivary gland damage
