摘要
目的分析双胎合并妊娠期肝内胆汁淤积症的临床特点。方法我院产科诊治的双胎妊娠患者515例,其中双胎妊娠合并妊娠期肝内胆汁淤积症17例为观察组,随机选取18例未合并肝内胆汁淤积症的双胎妊娠患者为对照组。观察并比较两组患者围生儿预后情况、孕妇生产方式及并发症发生情况。结果双胎妊娠合并妊娠期肝内胆汁淤积症的发病率为3.30%;观察组中发生胎儿窘迫、胎儿窒息及胎儿死亡的比例分别为41.2%、52.9%和35.3%,显著高于对照组的5.6%、11.1%和0(P<0.05);观察组患者中剖宫产比例为70.6%,显著高于对照组的33.3%(P<0.05);观察组患者发生妊高症及产后出血并发症的比例分别为58.8%和41.2%,均明显高于对照组的16.7%和5.6%(P<0.05)。结论双胎妊娠合并妊娠期肝内胆汁淤积症发病率高,胎儿预后较差,孕妇并发症多,临床工作中应该积极应对。
Objective To analyze the clinical characteristics of the twin pregnancy with intrahepatic cho- lestasis. Methods Five hundred and fifteen patients of twin pregnancy were chosen. Seventeen of the patients com- plicated with intrahepatic cholestasis were chosen as the study group, and 18 of the patients without intrahepatic cho- lestasis were chosen as the control group. The prognosis, maternal mode of production and occurrence of complica- tions were compared between the two groups. Results The incidence of twin pregnancy complicated with gestational intrahepatic cholestasis were 3.30%. The occurrence of fetal distress, fetal asphyxia and fetal death in the study group were 41.2%, 52.9% and 35.3%, respectively, significantly higher than those in the control group （5.6%, 11.1% and 0%, respectively）, P〈0.05. The incidence of cesarean section, the pregnancy induced hypertension and postpartum hemorrhage of the study group were 70.6%, 58.8% and 41.2%, respectively, significantly higher than those in the con- trol （33.3%, 16.7% and 5.6%, respectively）, P〈0.05. Conclusion Twin pregnancy is characterized by a high inci- dence of intrahepatic cholestasis syndrome, with poor fetal prognosis, more pregnant complications, which should be paid special attention to.
出处
《海南医学》
CAS
2012年第16期81-83,共3页
Hainan Medical Journal
关键词
双胎妊娠
肝内胆汁淤积症
胎儿
并发症
Twin pregnancy
Intrahepatic cholestasis
Fetus
Complications
