摘要
为评价雾化吸入支气管扩张剂对稳定期慢性阻塞性肺疾病 (COPD)患者肺功能及相关参数的影响。方法 :47例患者随机分为 A组 (15例 )、B组 (16例 )、C组 (16例 ) ,分别测定基础肺功能。A组吸入溴化异丙托品 0 .5 mg,B组吸入沙丁胺醇 5 m g,C组吸入沙丁胺醇 5 m g加溴化异丙托品 0 .5 mg,于第 1,11,2 1,2 2 d,测吸药后 30 min,1,2 ,4,5 ,6 ,7,8h的肺功能参数 (FEV1 ,FVC)。结果 :用药后在前 4h各组 FEV1 ,FVC较基础值有明显差异 (P<0 .0 1～ 0 .0 5 )。C组 FEV1 ,FVC改善率 (△ FEV1 、△ FVC)明显高于 A、 B组 ,有显著性差异 (P<0 .0 1) ,三组均无明显的副作用。结论 :联合应用的即时气道扩张作用较单用明显 (P<0 .0 5 ) ,沙丁胺醇 ,溴化异丙托品有相近的气道扩张作用。
Objective:To evaluate the effect of inhaled bronchodilators on pulmonary function and relevant parameter with stable COPD Methods:47 patients with COPD were divided into three groups at random (A,B and C) The baseline pulmonary function was measured separately;Group A:inhaled iprotpium;Group B:inhaled albuterol;Group C:inhaled iprotpium+allbuterol The subjects were tested on days 1,11,21,31,and pulmonary function values of 30 min,1 hour,2 hour,3 hour,4 hour,5 hour,6 hour,7 hour,8 hour were measured after inhaltion Result:In first 4 hours FEV 1,FVC increased in the three Groups after inhaltion (P<0 01).There was significant improvement of the mean peak percent increase in FEV 1 over baseline in Group C as compared with A * and B ** (*P<0 01,**P<0 05);Group A,B and C showed and no obvious effect Conclusion:(1)The stable COPD patients' mean bsaeline of FEV 1,FVC did not changed after inhalation in all groups (2)Bronchodilators had obvious bronchodilation The improvement of FEV 1 and FVC in Group C was superior to that of Group A and B Group A and B had similar bronchodilation
出处
《广西医科大学学报》
CAS
2000年第2期219-221,共3页
Journal of Guangxi Medical University
